The digestive tracts of a healthy adult contain approximately about 1011-1012 microorganisms, including bacteria and archaea, collectively referred to as the gut microbiota or intestinal flora. An individual's gut microbial flora is unique, acting as a separate set of "genomes" in the body. Recent studies have confirmed that altered intestinal flora and their metabolites significantly affect a variety of biological behaviors, including metabolism, organ development and immune response, which are significantly associated with human diseases, including but not limited to gastrointestinal disorders, obesity, diabetes, cancer, and even neurological and neurodegenerative diseases such as depression, autism, anxiety, and Parkinson's disease.
It is now well recognized that gut microbiota and their metabolites can affect the body's immune system in various ways, thereby regulating the progression of multiple diseases, including but not limited to inflammatory bowel disease, cancers, and diabetes. For example, intestinal flora regulates the immune system by influencing the tryptophan metabolic pathway. Bacterial components are presented directly as antigens and activate the immune system. "Intercommunication" between bacteria and host cells induces the secretion of inflammation-associated cytokines, thus recruiting immune cells and regulating immune homeostasis.
Given the important role of the interaction between the immune system and the gastrointestinal microbiota in human disease. It is worth exploring the mechanism of their interaction and elucidating the relationship between the gut microbiome, immunity, and human diseases, which would be significant to identify potential therapeutic strategies and targets for related diseases.
We encourage the exploration of the etiology of human immune-related diseases from the perspective of gut microecology to address these challenging questions. Both original studies and review articles with the following contents are highly anticipated for publication.
• Molecular mechanisms of interaction between gut microbes /metabolites and immune system.
• Effect of gut microbes /metabolites on the immune system and immune-related diseases.
• New therapies and targets based on the interaction between gut microbes/metabolites and the immune system for related diseases.
The digestive tracts of a healthy adult contain approximately about 1011-1012 microorganisms, including bacteria and archaea, collectively referred to as the gut microbiota or intestinal flora. An individual's gut microbial flora is unique, acting as a separate set of "genomes" in the body. Recent studies have confirmed that altered intestinal flora and their metabolites significantly affect a variety of biological behaviors, including metabolism, organ development and immune response, which are significantly associated with human diseases, including but not limited to gastrointestinal disorders, obesity, diabetes, cancer, and even neurological and neurodegenerative diseases such as depression, autism, anxiety, and Parkinson's disease.
It is now well recognized that gut microbiota and their metabolites can affect the body's immune system in various ways, thereby regulating the progression of multiple diseases, including but not limited to inflammatory bowel disease, cancers, and diabetes. For example, intestinal flora regulates the immune system by influencing the tryptophan metabolic pathway. Bacterial components are presented directly as antigens and activate the immune system. "Intercommunication" between bacteria and host cells induces the secretion of inflammation-associated cytokines, thus recruiting immune cells and regulating immune homeostasis.
Given the important role of the interaction between the immune system and the gastrointestinal microbiota in human disease. It is worth exploring the mechanism of their interaction and elucidating the relationship between the gut microbiome, immunity, and human diseases, which would be significant to identify potential therapeutic strategies and targets for related diseases.
We encourage the exploration of the etiology of human immune-related diseases from the perspective of gut microecology to address these challenging questions. Both original studies and review articles with the following contents are highly anticipated for publication.
• Molecular mechanisms of interaction between gut microbes /metabolites and immune system.
• Effect of gut microbes /metabolites on the immune system and immune-related diseases.
• New therapies and targets based on the interaction between gut microbes/metabolites and the immune system for related diseases.
