Animal models are widely used to study disease mechanisms and have been successfully employed to test new biotechnological, chemical, or herbal therapeutics for human diseases. The NCBI database lists around 900,000 studies using animal models for various diseases, overcoming the limitations of human clinical trials. Ideally, animal models need to have similar pathology to the human disease. However, many models reflect only certain aspects of a pathology. The latter is particularly the case for rodent models.
Human culture has great influence on the diet and living conditions of large mammals such as dogs, cats, pigs, and cattle. These domestic and livestock animals experience very similar influences on their homeostasis as humans. It is therefore no surprise that human diseases are found in a similar form in domestic and livestock animals, including cell degeneration-based diseases. Such disorders, ranging from neurodegenerative disease to cancers, are playing an increasingly important role in the health of society. For example, the association of hepatocyte cell death in non-alcoholic fatty liver with increased incidence of hepatocellular carcinoma. The potential of the livestock animal models in particular, provides researchers with the opportunity to understand disease pathology as well as find new therapeutic approaches for disease treatment. Even in cases where there are differences in disease onset and manifestation between humans and animals, there is an opportunity to reveal fundamental insights into a disease.
This Research Topic will highlight in which diseases the analysis of animal models, particularly livestock animal models, with the same pathology as humans, offers special insights into the mechanisms and therapeutic options for cell degeneration disorders. Subtopics include but are not limited to:
• Mechanistic insights into cell degeneration disorders (cell death programs)
• Animal disorders resembling human pathologies (focus on livestock animals)
• Veterinary clinical aspects (cancer, trauma, infection, or metabolic)
• One health approaches (def. Wiki)
Animal models are widely used to study disease mechanisms and have been successfully employed to test new biotechnological, chemical, or herbal therapeutics for human diseases. The NCBI database lists around 900,000 studies using animal models for various diseases, overcoming the limitations of human clinical trials. Ideally, animal models need to have similar pathology to the human disease. However, many models reflect only certain aspects of a pathology. The latter is particularly the case for rodent models.
Human culture has great influence on the diet and living conditions of large mammals such as dogs, cats, pigs, and cattle. These domestic and livestock animals experience very similar influences on their homeostasis as humans. It is therefore no surprise that human diseases are found in a similar form in domestic and livestock animals, including cell degeneration-based diseases. Such disorders, ranging from neurodegenerative disease to cancers, are playing an increasingly important role in the health of society. For example, the association of hepatocyte cell death in non-alcoholic fatty liver with increased incidence of hepatocellular carcinoma. The potential of the livestock animal models in particular, provides researchers with the opportunity to understand disease pathology as well as find new therapeutic approaches for disease treatment. Even in cases where there are differences in disease onset and manifestation between humans and animals, there is an opportunity to reveal fundamental insights into a disease.
This Research Topic will highlight in which diseases the analysis of animal models, particularly livestock animal models, with the same pathology as humans, offers special insights into the mechanisms and therapeutic options for cell degeneration disorders. Subtopics include but are not limited to:
• Mechanistic insights into cell degeneration disorders (cell death programs)
• Animal disorders resembling human pathologies (focus on livestock animals)
• Veterinary clinical aspects (cancer, trauma, infection, or metabolic)
• One health approaches (def. Wiki)
