Over the years, the mechanisms that control inflammation and immunological responses have been extensively described and targeted for effective resolution, especially in infection-driven diseases. Since discovery of inflammasomes, researchers have concentrated their efforts in understanding the role of these multiprotein platforms in the development of innate immune response and in the strategies of microbial evasion and cell death pathways. The changes that occur in intracellular metabolic pathways during immune cell activation are explored in the field of immunometabolism. The connection of the major metabolic pathways with inflammasome activation is an emerging and complex interplay that may provide a different dimension to our current understanding of the immune system in health and disease. In this context, the role of extracellular nucleotide signaling or purinergic signaling adds an important layer of interaction of receptors capable of orchestrating cell function.
Immune cells are controlled by numerous metabolic pathways that can change their behavior to interact with various antigens. Immunometabolism links immunological and metabolic processes and is an essential and complex layer for innate and adaptive immunity. The metabolic program of cells can determine cell survival, function, differentiation, and often its dysregulation mediate inflammatory diseases.
The goal of this Research Topic is to supply the noticeable demand for evidence exploring the interplay between metabolic reprogramming, inflammasome activation and nucleotide signaling in immunity with special emphasis in oral health and disease.
This Research Topic welcomes high-quality Original Research, mini reviews, reviews, and perspective articles in relation to oral health and disease that aim to:
• Report observations of immune and non-immune cell metabolism and its impact in immune response
• Describe mechanistic understanding of how cell metabolic pathways shape the immune response and inflammasome activation
• Offer insights into possible interplay between the inflammasome, purinergic signaling and immunometabolism
• Critically review the current literature about the connection of inflammasome activation and purinergic signaling focusing on how this interplay may change cell metabolism and/or metabolic reprogramming
Over the years, the mechanisms that control inflammation and immunological responses have been extensively described and targeted for effective resolution, especially in infection-driven diseases. Since discovery of inflammasomes, researchers have concentrated their efforts in understanding the role of these multiprotein platforms in the development of innate immune response and in the strategies of microbial evasion and cell death pathways. The changes that occur in intracellular metabolic pathways during immune cell activation are explored in the field of immunometabolism. The connection of the major metabolic pathways with inflammasome activation is an emerging and complex interplay that may provide a different dimension to our current understanding of the immune system in health and disease. In this context, the role of extracellular nucleotide signaling or purinergic signaling adds an important layer of interaction of receptors capable of orchestrating cell function.
Immune cells are controlled by numerous metabolic pathways that can change their behavior to interact with various antigens. Immunometabolism links immunological and metabolic processes and is an essential and complex layer for innate and adaptive immunity. The metabolic program of cells can determine cell survival, function, differentiation, and often its dysregulation mediate inflammatory diseases.
The goal of this Research Topic is to supply the noticeable demand for evidence exploring the interplay between metabolic reprogramming, inflammasome activation and nucleotide signaling in immunity with special emphasis in oral health and disease.
This Research Topic welcomes high-quality Original Research, mini reviews, reviews, and perspective articles in relation to oral health and disease that aim to:
• Report observations of immune and non-immune cell metabolism and its impact in immune response
• Describe mechanistic understanding of how cell metabolic pathways shape the immune response and inflammasome activation
• Offer insights into possible interplay between the inflammasome, purinergic signaling and immunometabolism
• Critically review the current literature about the connection of inflammasome activation and purinergic signaling focusing on how this interplay may change cell metabolism and/or metabolic reprogramming