Metalloproteinases are critically important for the regulation of many physiological and pathological processes (e.g. protein degradation and nucleic acid modification) due to their capability to mediate methylation, phosphorylation, acetylation, ubiquitination, hydroxylation, amidation, hydrogenation, deamination of histone or non-histone. In particular, numerous metalloproteinases are able to directly or indirectly regulate the activity of chemokines, thereby controlling many aspects of inflammation and innate immunity. Understanding the roles of metalloproteinases in the immune system may uncover innovative and potential targets for the diagnosis and treatment of chronic inflammatory diseases. Although recent advances in molecular biology have substantially improved our understanding of metalloproteinases, their immunomodulatory roles, functions, and mechanisms in chronic inflammatory diseases remain unclear.
Along with the recent progress, efforts have been devoted to investigating the immunoregulation of metalloproteinases in chronic inflammatory diseases using techniques such as single-cell sequencing, spatial transcriptomic analysis, whole-genome sequencing, and targeted sequencing. A range of metalloproteinase-targeting compounds in the forms of therapeutic drugs and imaging probes have also been developed. However, this research field is still in its infancy stage and further research work is needed. The aim of this special issue is to explore the immunoregulatory function and mechanism of metalloproteinases in chronic inflammatory diseases, as well as the potential of using metalloproteinase-targeting compounds for the treatment and/or diagnosis of chronic inflammatory diseases, especially cancer, inflammatory bowel disease, rheumatism, and so on.
This special issue aims to present state-of-the-art research that uncovers the immunoregulatory roles, functions, and mechanism of actions of metalloproteinases in chronic inflammatory diseases, as well as the uses of metalloproteinase-targeting compounds as new approaches for the treatment of chronic inflammatory diseases.
The special issue will comprise a selection of Original Research articles, Methods, and Reviews. We welcome the potential subjects include, but are not limited to, the following subtopics:
(1) Immunomodulatory roles, functions, and mechanisms of metalloproteinases in chronic inflammatory diseases and the signal transduction pathways involved.
(2) Construction of cellular network map to study the contribution of metalloenzymes to susceptibility and disease progression in chronic inflammatory diseases.
(3) Metalloproteinase as modulators of innate immunity and chronic inflammation.
(4) Metalloproteinase-targeting compounds as immunomodulators for the treatment of chronic inflammatory diseases.
(5) Metalloproteinase-targeting/responsive compounds as imaging probes to study the immunoactivity of metalloproteinase in chronic inflammatory diseases.
(6) Other topics related to the relationship between metalloproteinase, innate immunity, and chronic inflammation are also welcome.
Metalloproteinases are critically important for the regulation of many physiological and pathological processes (e.g. protein degradation and nucleic acid modification) due to their capability to mediate methylation, phosphorylation, acetylation, ubiquitination, hydroxylation, amidation, hydrogenation, deamination of histone or non-histone. In particular, numerous metalloproteinases are able to directly or indirectly regulate the activity of chemokines, thereby controlling many aspects of inflammation and innate immunity. Understanding the roles of metalloproteinases in the immune system may uncover innovative and potential targets for the diagnosis and treatment of chronic inflammatory diseases. Although recent advances in molecular biology have substantially improved our understanding of metalloproteinases, their immunomodulatory roles, functions, and mechanisms in chronic inflammatory diseases remain unclear.
Along with the recent progress, efforts have been devoted to investigating the immunoregulation of metalloproteinases in chronic inflammatory diseases using techniques such as single-cell sequencing, spatial transcriptomic analysis, whole-genome sequencing, and targeted sequencing. A range of metalloproteinase-targeting compounds in the forms of therapeutic drugs and imaging probes have also been developed. However, this research field is still in its infancy stage and further research work is needed. The aim of this special issue is to explore the immunoregulatory function and mechanism of metalloproteinases in chronic inflammatory diseases, as well as the potential of using metalloproteinase-targeting compounds for the treatment and/or diagnosis of chronic inflammatory diseases, especially cancer, inflammatory bowel disease, rheumatism, and so on.
This special issue aims to present state-of-the-art research that uncovers the immunoregulatory roles, functions, and mechanism of actions of metalloproteinases in chronic inflammatory diseases, as well as the uses of metalloproteinase-targeting compounds as new approaches for the treatment of chronic inflammatory diseases.
The special issue will comprise a selection of Original Research articles, Methods, and Reviews. We welcome the potential subjects include, but are not limited to, the following subtopics:
(1) Immunomodulatory roles, functions, and mechanisms of metalloproteinases in chronic inflammatory diseases and the signal transduction pathways involved.
(2) Construction of cellular network map to study the contribution of metalloenzymes to susceptibility and disease progression in chronic inflammatory diseases.
(3) Metalloproteinase as modulators of innate immunity and chronic inflammation.
(4) Metalloproteinase-targeting compounds as immunomodulators for the treatment of chronic inflammatory diseases.
(5) Metalloproteinase-targeting/responsive compounds as imaging probes to study the immunoactivity of metalloproteinase in chronic inflammatory diseases.
(6) Other topics related to the relationship between metalloproteinase, innate immunity, and chronic inflammation are also welcome.
