Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disease associated with significant morbidity, increased mortality rate, and poor quality of life. It is characterized by the involvement of a diverse multisystem and the production of an array of autoantibodies. A complex interplay of genes, environment, sexual hormones, immune dysfunction and aberrant apoptosis have been implicated in the pathogenesis of SLE, but the actual etiology remains unclear. Moreover, the traditional drugs, such as glucocorticoids and immunosuppressants, widely used for the relief of SLE have not been found to effectively decrease the production of pathogenetic autoantibodies. Therefore, studies on the pathogenesis of SLE are essential to find out new targets, in order to improve the diagnosis and therapies.
In recent years, nanomaterials have attracted much attention for drug delivery, diagnosis and imaging, synthetic vaccine development and miniature medical devices. Herein, we want to promote the application of nanomaterials in SLE , to enhance diagnosis and treatment. This Research Topic aims to highlight recent advances in the pathogenesis of SLE to provide a theoretical basis for the development of new diagnostic methods, therapeutic modalities, focused on the use of nanomaterials.
We welcome submissions of Original Research, Reviews, Mini-reviews, including but not limited to, the following topics:
1. Novel therapeutic strategies of SLE targeting immune cells
2. Specific nanomaterials for the diagnosis and treatment of SLE
Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disease associated with significant morbidity, increased mortality rate, and poor quality of life. It is characterized by the involvement of a diverse multisystem and the production of an array of autoantibodies. A complex interplay of genes, environment, sexual hormones, immune dysfunction and aberrant apoptosis have been implicated in the pathogenesis of SLE, but the actual etiology remains unclear. Moreover, the traditional drugs, such as glucocorticoids and immunosuppressants, widely used for the relief of SLE have not been found to effectively decrease the production of pathogenetic autoantibodies. Therefore, studies on the pathogenesis of SLE are essential to find out new targets, in order to improve the diagnosis and therapies.
In recent years, nanomaterials have attracted much attention for drug delivery, diagnosis and imaging, synthetic vaccine development and miniature medical devices. Herein, we want to promote the application of nanomaterials in SLE , to enhance diagnosis and treatment. This Research Topic aims to highlight recent advances in the pathogenesis of SLE to provide a theoretical basis for the development of new diagnostic methods, therapeutic modalities, focused on the use of nanomaterials.
We welcome submissions of Original Research, Reviews, Mini-reviews, including but not limited to, the following topics:
1. Novel therapeutic strategies of SLE targeting immune cells
2. Specific nanomaterials for the diagnosis and treatment of SLE
