The acceleration of the number of the aging global population brings about formidable healthcare challenges. By 2050, there will be 1.5 billion people aged 65+. In 2019, the proportion of older surgical adults exceeds approximately 50% in the United States. Aging is usually accompanied by decreased functional reserve, increased injurious susceptibility, undesirable comorbidities, and therefore reduced capacity to recover from postoperative complications. The prevalence of postoperative cognitive decline in the older population took up to 25-45% in elective surgery. Advanced age, baseline functional capacity, frailty, and several comorbidities are associated with cognitive changes in older adults. This complication leads to prolonged hospitalization, increased mortality, and a growing burden on the medical care system. Though increasing attention has been paid to this issue during recent decades, the underlying mechanism is still under debate, and promising clinically translating preventive measures need to be further explored.
In this context, the aims of the present Research Topic are to
• update the mechanism underlying postoperative cognitive dysfunction with comorbidities, such as type 2 diabetes, Alzheimer's disease, obstructive sleep apnea, and Parkinson’s disease
• explore the promising measurements to prevent this neurological complication in clinical and preclinical research.
• to gather studies that modify or develop behavioral-evaluation toolkits specific to the aged population with visual or auditory decline.
In this Research Topic, a broad scope of articles including original research, reviews, mini-reviews on basic and clinical research are welcomed in submission.
The acceleration of the number of the aging global population brings about formidable healthcare challenges. By 2050, there will be 1.5 billion people aged 65+. In 2019, the proportion of older surgical adults exceeds approximately 50% in the United States. Aging is usually accompanied by decreased functional reserve, increased injurious susceptibility, undesirable comorbidities, and therefore reduced capacity to recover from postoperative complications. The prevalence of postoperative cognitive decline in the older population took up to 25-45% in elective surgery. Advanced age, baseline functional capacity, frailty, and several comorbidities are associated with cognitive changes in older adults. This complication leads to prolonged hospitalization, increased mortality, and a growing burden on the medical care system. Though increasing attention has been paid to this issue during recent decades, the underlying mechanism is still under debate, and promising clinically translating preventive measures need to be further explored.
In this context, the aims of the present Research Topic are to
• update the mechanism underlying postoperative cognitive dysfunction with comorbidities, such as type 2 diabetes, Alzheimer's disease, obstructive sleep apnea, and Parkinson’s disease
• explore the promising measurements to prevent this neurological complication in clinical and preclinical research.
• to gather studies that modify or develop behavioral-evaluation toolkits specific to the aged population with visual or auditory decline.
In this Research Topic, a broad scope of articles including original research, reviews, mini-reviews on basic and clinical research are welcomed in submission.