The orderly structure of bone and cartilage is the key to maintaining its motor function and mechanical support. During skeleton formation, bone and cartilage undergo co-progressive evolution, i.e., intramembranous or intrachondral osteogenesis, then an osteogenic center develops into complex structures such as the spine and long bones. Likewise, the homeostatic process of orderly regulation also occurs after bone trauma. In fact, the maintenance of bone-cartilage homeostasis has always been the focus of attention. The impairment of it will directly lead to bone-cartilage degenerative diseases like osteoarthritis and related disorders When aging occurs or other endocrine system changes that are associated with it. In the view of cellular metabolism, chondrocytes and osteocytes are considered less active cells. But it is worth pondering that they are one of the keys to maintaining bone-cartilage homeostasis. For example, how do chondrocytes and osteocytes communicate with other "dwellers" (such as vascular endothelial cells) and visitors (immune cells) within the bone tissue? Therefore, studying the role of cell metabolism in bone-cartilage homeostasis is crucial for elucidating life development and treating bone degenerative diseases.
This Research Topic aims to elucidate the regulatory mechanisms of bone-cartilage homeostasis from physiological and pathological perspectives, as well as the function of cellular metabolism in this progress. By seeking the crosstalk model or metabolic patterns, we want to answer questions about how chondrocytes and cells within bone interact with each other. This Research Topic is also devoted to achieving potential metabolic treatment targets of degenerative bone diseases like osteoarthritis while elucidating the mechanism of bone-cartilage homeostasis maintenance.
Potential sub-themes include, but are not limited to:
• Regulatory mechanisms of bone-cartilage homeostasis
• Interaction patterns of osteocyte/chondrocytes and other cells (e.g., vascular endothelium, osteoblast, osteoclast, or immune cells)
• Single-cell studies of bone homeostasis regulation
• Metabolic behavior of bone tissue cells
• Potential therapeutic targets and drug research for bone-cartilage degenerative diseases
• How the endocrine system is involved in the crosstalk between bone-cartilage
The orderly structure of bone and cartilage is the key to maintaining its motor function and mechanical support. During skeleton formation, bone and cartilage undergo co-progressive evolution, i.e., intramembranous or intrachondral osteogenesis, then an osteogenic center develops into complex structures such as the spine and long bones. Likewise, the homeostatic process of orderly regulation also occurs after bone trauma. In fact, the maintenance of bone-cartilage homeostasis has always been the focus of attention. The impairment of it will directly lead to bone-cartilage degenerative diseases like osteoarthritis and related disorders When aging occurs or other endocrine system changes that are associated with it. In the view of cellular metabolism, chondrocytes and osteocytes are considered less active cells. But it is worth pondering that they are one of the keys to maintaining bone-cartilage homeostasis. For example, how do chondrocytes and osteocytes communicate with other "dwellers" (such as vascular endothelial cells) and visitors (immune cells) within the bone tissue? Therefore, studying the role of cell metabolism in bone-cartilage homeostasis is crucial for elucidating life development and treating bone degenerative diseases.
This Research Topic aims to elucidate the regulatory mechanisms of bone-cartilage homeostasis from physiological and pathological perspectives, as well as the function of cellular metabolism in this progress. By seeking the crosstalk model or metabolic patterns, we want to answer questions about how chondrocytes and cells within bone interact with each other. This Research Topic is also devoted to achieving potential metabolic treatment targets of degenerative bone diseases like osteoarthritis while elucidating the mechanism of bone-cartilage homeostasis maintenance.
Potential sub-themes include, but are not limited to:
• Regulatory mechanisms of bone-cartilage homeostasis
• Interaction patterns of osteocyte/chondrocytes and other cells (e.g., vascular endothelium, osteoblast, osteoclast, or immune cells)
• Single-cell studies of bone homeostasis regulation
• Metabolic behavior of bone tissue cells
• Potential therapeutic targets and drug research for bone-cartilage degenerative diseases
• How the endocrine system is involved in the crosstalk between bone-cartilage