The prevalence of metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and nonalcoholic fatty liver disease (NAFLD) has become a severe public health problem. Human gut microbiota is a complex and dynamic ecosystem and can regulate host metabolism by influencing immune maturation and homeostasis, protecting against pathogen overgrowth, regulating intestinal endocrine functions and neurologic signaling, modulating energy metabolism, and producing functional metabolites. The compositional and metabolic changes of intestinal microbiota (dysbiosis) are closely involved in the occurrence of metabolic diseases. Increasing evidence has demonstrated that the baseline level of certain beneficial bacteria is essential for the effectiveness of the therapy. Diet is a key modifiable factor affecting the composition and function of the gut microbiota, indicating the potential for therapeutic dietary strategies to manipulate gut microbiota. Thus, considerable attention has been paid to gut microbiota-targeted therapies on metabolic diseases, such as diet supplementation with nutrients, probiotics, prebiotics, plant extracts, natural compounds, etc., aimed to counteract the dysbiosis-related deleterious consequences.
The major goal of this Research Topic is to provide evidence for how dietary supplementation modulates gut microbiota composition and function, as well as gut bacterial metabolites, which improves host metabolic health. We expect that by combining metagenomics, metabolomics, proteomics, transcriptomics, and omics to find new linkages between dietary factors, intestinal microbiota, and health, we will be able to learn more about the molecular mechanisms of diet-gut microbiota regulation and interaction.
This Research Topic is to assemble Original Research articles and Reviews addressing the questions related to the essential role of gut microbiota:
1) Function of dietary interventions such as nutrients, probiotics, prebiotics, plant extracts, and natural compounds in the modulation of the host gut microbiota in health and disease.
2) Mechanistic study of dietary supplementation on regulating gut microbiota composition and function as well as gut microbiota metabolites which in turn improve metabolic disorders.
3) The dynamic changes of gut microbiota during dietary supplementation to improve metabolic disorders.
4) Multi-omics analysis to study the interaction of diet supplementation and gut microbiota.
The prevalence of metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and nonalcoholic fatty liver disease (NAFLD) has become a severe public health problem. Human gut microbiota is a complex and dynamic ecosystem and can regulate host metabolism by influencing immune maturation and homeostasis, protecting against pathogen overgrowth, regulating intestinal endocrine functions and neurologic signaling, modulating energy metabolism, and producing functional metabolites. The compositional and metabolic changes of intestinal microbiota (dysbiosis) are closely involved in the occurrence of metabolic diseases. Increasing evidence has demonstrated that the baseline level of certain beneficial bacteria is essential for the effectiveness of the therapy. Diet is a key modifiable factor affecting the composition and function of the gut microbiota, indicating the potential for therapeutic dietary strategies to manipulate gut microbiota. Thus, considerable attention has been paid to gut microbiota-targeted therapies on metabolic diseases, such as diet supplementation with nutrients, probiotics, prebiotics, plant extracts, natural compounds, etc., aimed to counteract the dysbiosis-related deleterious consequences.
The major goal of this Research Topic is to provide evidence for how dietary supplementation modulates gut microbiota composition and function, as well as gut bacterial metabolites, which improves host metabolic health. We expect that by combining metagenomics, metabolomics, proteomics, transcriptomics, and omics to find new linkages between dietary factors, intestinal microbiota, and health, we will be able to learn more about the molecular mechanisms of diet-gut microbiota regulation and interaction.
This Research Topic is to assemble Original Research articles and Reviews addressing the questions related to the essential role of gut microbiota:
1) Function of dietary interventions such as nutrients, probiotics, prebiotics, plant extracts, and natural compounds in the modulation of the host gut microbiota in health and disease.
2) Mechanistic study of dietary supplementation on regulating gut microbiota composition and function as well as gut microbiota metabolites which in turn improve metabolic disorders.
3) The dynamic changes of gut microbiota during dietary supplementation to improve metabolic disorders.
4) Multi-omics analysis to study the interaction of diet supplementation and gut microbiota.