Advances in Brain Disorders: from Mechanisms to Therapeutic Targets

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Editorial

28 November 2023

Editorial: Advances in brain disorders: from mechanisms to therapeutic targets

Federica Bono

,

Giulia Abate

,

Sara Anna Bonini

,

Maria Josè Sisalli

and

Arianna Bellucci

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Editors

5

Arianna Bellucci

University of Brescia

Federica Bono

University of Brescia

Sara Anna Bonini

University of Brescia

Maria Jose Sisalli

University of Naples Federico II

GIULIA ABATE

University of Brescia

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About

This Research Topic is in Partnership with the 2022 "Italian Society for Neuroscience National Meeting of PhD Students in Neuroscience conference."

Neurological disorders such as Alzheimer’s disease and other dementias, Parkinson’s disease, multiple sclerosis, traumatic brain injury, epilepsy, migraine, depression, stroke, and neurodevelopmental disorders such as schizophrenia or autism spectrum disorders account for one-third of the burden of all diseases in the wealthy part of the world. These represent one of the biggest challenges for National Health Systems in terms of economic costs. For instance, it has been estimated that in 2004, 127 million European citizens were living with a brain disorder, for a total annual cost of 385 billion euros. Unfortunately, for most brain disorders, we are still missing effective therapies because since many years we are facing the unmet need of defining the key molecular underpinnings of disease. However, it is clear that the integration of data deriving from basic and clinical research studies is pivotal for a better comprehension of the biological basis of brain disorders and for the identification of novel therapeutic targets to develop innovative pharmacological approaches.

This Research Topic aims at integrating basic and clinical research reports, reviews or viewpoints presenting novel mechanisms involved in acute and chronic brain disorders, highlighting the identification of innovative therapeutic targets or discussing gaps and controversies related to experimental models or therapeutic management of brain disorders.

This Research Topic will collect full research reports, review articles, meta-analyses or viewpoints. Studies examining all levels of inquiry, from basic to applied or clinical science and also methodological papers using a wide range of techniques and model systems, are welcome.

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Editors

Arianna Bellucci

University of Brescia

Federica Bono

University of Brescia

Sara Anna Bonini

University of Brescia

Maria Jose Sisalli

University of Naples Federico II

GIULIA ABATE

University of Brescia

Coordinators

Viviana Trezza

Daniela Uberti

Impact

79,250 Total views

56,607 Article views

21,502 Article downloads

1,141 Topic views

Published In

Frontiers in Molecular Neuroscience

Brain Disease Mechanisms

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