Musculoskeletal health is becoming a global health issue with the increasing aging population. The development, maintenance and degeneration of bone, cartilage and other ligaments play crucial roles in maintaining musculoskeletal health, as well as bone and joint function. However, the molecular and regulatory mechanisms of bone cartilage formation and degeneration is complex, especially in a variety of musculoskeletal pathologies such as osteoarthritis, osteoporosis and ligament tear. Understanding the intricate regulatory networks of bone and cartilage homeostasis, as well as developing targeted drugs, can significantly improve therapeutic approaches and efficacy in treating these diseases. Furthering our knowledge and understanding of the signaling interactions during bone and cartilage formation and degeneration is critical for the treatment of musculoskeletal degenerative diseases and injuries. The discovery of key regulatory proteins and essential signaling pathways will assist in the development of novel targeted drugs and translational medicine in the near future.
The goal of this Research Topic is to collect Original Research and Review articles that will aid in the discovery of complex regulatory mechanisms underlying bone and cartilage degeneration, and the development of novel treatment approaches and translational medicine. Potential subtopics include, but are not limited to:
- Molecular mechanisms and signaling of bone development and metabolism;
- Molecular regulatory mechanisms and signaling during cartilage formation and degeneration in osteoarthritis;
- Crosstalk between degenerative and/or inflammatory tissues in joints, including subchondral bone, cartilage, meniscus and synovium;
- Cellular interactions among meniscus, cartilage and synovium;
- Joint ligament degeneration, tear and reconstruction;
- Pre-clinical translational medicine for bone and cartilage degenerative diseases.
Musculoskeletal health is becoming a global health issue with the increasing aging population. The development, maintenance and degeneration of bone, cartilage and other ligaments play crucial roles in maintaining musculoskeletal health, as well as bone and joint function. However, the molecular and regulatory mechanisms of bone cartilage formation and degeneration is complex, especially in a variety of musculoskeletal pathologies such as osteoarthritis, osteoporosis and ligament tear. Understanding the intricate regulatory networks of bone and cartilage homeostasis, as well as developing targeted drugs, can significantly improve therapeutic approaches and efficacy in treating these diseases. Furthering our knowledge and understanding of the signaling interactions during bone and cartilage formation and degeneration is critical for the treatment of musculoskeletal degenerative diseases and injuries. The discovery of key regulatory proteins and essential signaling pathways will assist in the development of novel targeted drugs and translational medicine in the near future.
The goal of this Research Topic is to collect Original Research and Review articles that will aid in the discovery of complex regulatory mechanisms underlying bone and cartilage degeneration, and the development of novel treatment approaches and translational medicine. Potential subtopics include, but are not limited to:
- Molecular mechanisms and signaling of bone development and metabolism;
- Molecular regulatory mechanisms and signaling during cartilage formation and degeneration in osteoarthritis;
- Crosstalk between degenerative and/or inflammatory tissues in joints, including subchondral bone, cartilage, meniscus and synovium;
- Cellular interactions among meniscus, cartilage and synovium;
- Joint ligament degeneration, tear and reconstruction;
- Pre-clinical translational medicine for bone and cartilage degenerative diseases.
