Clinical and Genetic Determinants of Diabetes and Complications

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Editorial

04 July 2023

Editorial: Clinical and genetic determinants of diabetes and complications

Sen Li

,

Maurizio Delvecchio

,

Kunka Mohanram Ramkumar

,

Xiaowen Mao

, 1 more and

Shuzhen Guo

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Editors

6

Beijing University of Chinese Medicine

Maurizio Delvecchio

University of L'Aquila

University of Macau

Beijing University of Chinese Medicine

AFFILIATED HOSPITAL OF SHANDONG SECOND MEDICAL UNIVERSITY

Ramkumar Kunka Mohanram

SRM Institute of Science and Technology

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Diabetes Mellitus (DM) remains one of the leading causes of death around the world, which leads to a heavy global burden on public health. As predicted by International Diabetes Federation, a 50% increase in the number of patients with DM will be reached by 2030 compared to 366 million in 2011. DM has multiple complications that cause the injury of several organs such as heart and kidneys, leading to a reduction in quality of life and a higher premature mortality rate. For example, diabetic patients have two-fold increased risk for cardiovascular mortality. The pathogenesis of DM is multifactorial, and several clinical risk factors, such as being overweight or obese, have been proposed. But the contributions of several other putative factors on the pathogenesis of DM are still inconclusive. At genetic level, a family history of DM increases DM risk, and more than 500 genetic loci have been found to be associated with DM. However, the genetic determinants of DM complications are less understood. Most importantly, we are far from understanding the complex interaction effects of clinical and genetic factors on DM risk.

In this Research Topic, we hope to create a forum for the new insights into understanding the role of clinical and genetic risk factors as well as their potential interaction in the pathogenesis of diabetes and its complications. We welcome submissions of Original research articles, Review articles, Opinions and Perspectives, in the subtopics of the following, but not limited to:

• Clinical risk factors that contribute to the pathogenesis of diabetes
• Clinical risk factors affecting the development of complications in diabetic patients
• Genetic basis of diabetes and its complications
• The role of interaction between clinical and genetic risk factors in diabetes

Diabetes Mellitus (DM) remains one of the leading causes of death around the world, which leads to a heavy global burden on public health. As predicted by International Diabetes Federation, a 50% increase in the number of patients with DM will be reached by 2030 compared to 366 million in 2011. DM has multiple complications that cause the injury of several organs such as heart and kidneys, leading to a reduction in quality of life and a higher premature mortality rate. For example, diabetic patients have two-fold increased risk for cardiovascular mortality. The pathogenesis of DM is multifactorial, and several clinical risk factors, such as being overweight or obese, have been proposed. But the contributions of several other putative factors on the pathogenesis of DM are still inconclusive. At genetic level, a family history of DM increases DM risk, and more than 500 genetic loci have been found to be associated with DM. However, the genetic determinants of DM complications are less understood. Most importantly, we are far from understanding the complex interaction effects of clinical and genetic factors on DM risk.

In this Research Topic, we hope to create a forum for the new insights into understanding the role of clinical and genetic risk factors as well as their potential interaction in the pathogenesis of diabetes and its complications. We welcome submissions of Original research articles, Review articles, Opinions and Perspectives, in the subtopics of the following, but not limited to:

• Clinical risk factors that contribute to the pathogenesis of diabetes
• Clinical risk factors affecting the development of complications in diabetic patients
• Genetic basis of diabetes and its complications
• The role of interaction between clinical and genetic risk factors in diabetes

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Editors

Beijing University of Chinese Medicine

Maurizio Delvecchio

University of L'Aquila

University of Macau

Beijing University of Chinese Medicine

AFFILIATED HOSPITAL OF SHANDONG SECOND MEDICAL UNIVERSITY

Ramkumar Kunka Mohanram

SRM Institute of Science and Technology

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162,913 Total views

104,274 Article views

55,461 Article downloads

3,178 Topic views

Published In

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Frontiers in Endocrinology

Clinical Diabetes

Journal Thumbnail

Frontiers in Public Health

Clinical Diabetes

Journal Thumbnail

Frontiers in Neuroscience

Clinical Diabetes

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Frontiers in Nutrition

Clinical Diabetes

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