Potential Biomarkers in Neurovascular Disorders, volume II

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Chinese Academy of Medical Sciences and Peking Union Medical College

University of Arizona

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This Research Topic is the second volume of Research Topic "Potential Biomarkers in Neurovascular Disorders". Please see the first volume here.

Neurovascular disorders are a group of pathological conditions resulting from the neurovascular injury. Neurovascular disorders include cerebral ischemia, intracerebral hemorrhage, subarachnoid hemorrhage, venous sinus thrombosis, glioma, carotid disease, cerebral small vessel disease, and vascular dementia, among others. Although we have accumulated more understanding of both the genetic links and the basic mechanisms behind the pathophysiology of neurovascular diseases over the years, the exact mechanisms are still unclear. Therefore, there is an urgency to identify important therapeutic targets.

The determination of biomarkers plays an important role in the prevention, treatment, and improvement of the prognosis of diseases, and in providing new ideas for further determining causes and mechanisms. Changes in tissue fluids such as blood or cerebrospinal fluid reflect changes in brain parenchymal structure or function and provide key clues in exploring the etiology and mechanism of the disease. Similarly, changes in biomarkers at different stages of disease progression reflect categorization of the disease or variations of factors causing the same disease. Thus, biomarkers bear great importance to accurate diagnosis and precise treatment. For specific neurological diseases, such as vascular dementia, CADASIL, stroke, epilepsy, cerebral small vessel disease, vascular cognitive impairment, glioma, spinal cord injury, etc, researchers are still looking for biomarkers with high sensitivity and specificity. The discovery of highly efficient biomarkers may partially replace some of the gold standards for invasive diagnosis, enabling a new era of non-invasive or low-invasive precision and individualized treatment.

This Research Topic aims to collect novel articles investigating the clinical application of biomarkers for neurovascular disorders, as well as innovation and developments in biomarkers in such disorders. We also encourage submissions probing the mechanisms underlying neurovascular disorders, including but not limited to, Alzheimer’s disease, ischemic stroke, cerebral small vessel disease, intracerebral hemorrhage, subarachnoid hemorrhage, venous sinus thrombosis, glioma, carotid disease, and vascular dementia.

Both Original Research and Review articles are welcomed.

Topics of interest include but are not limited to:

• Peripheral blood or cerebrospinal fluid biomarkers for neurovascular disorders
• Imaging markers for neurovascular disorders
• Research on pathogenic genes in neurovascular disorders
• Neurovascular disorders and disorders of diet, exercise, and intestinal flora
• Bioinformatics analysis of the prevention, treatment, and prognosis of neurovascular disorders

This Research Topic is the second volume of Research Topic "Potential Biomarkers in Neurovascular Disorders". Please see the first volume here.

Neurovascular disorders are a group of pathological conditions resulting from the neurovascular injury. Neurovascular disorders include cerebral ischemia, intracerebral hemorrhage, subarachnoid hemorrhage, venous sinus thrombosis, glioma, carotid disease, cerebral small vessel disease, and vascular dementia, among others. Although we have accumulated more understanding of both the genetic links and the basic mechanisms behind the pathophysiology of neurovascular diseases over the years, the exact mechanisms are still unclear. Therefore, there is an urgency to identify important therapeutic targets.

The determination of biomarkers plays an important role in the prevention, treatment, and improvement of the prognosis of diseases, and in providing new ideas for further determining causes and mechanisms. Changes in tissue fluids such as blood or cerebrospinal fluid reflect changes in brain parenchymal structure or function and provide key clues in exploring the etiology and mechanism of the disease. Similarly, changes in biomarkers at different stages of disease progression reflect categorization of the disease or variations of factors causing the same disease. Thus, biomarkers bear great importance to accurate diagnosis and precise treatment. For specific neurological diseases, such as vascular dementia, CADASIL, stroke, epilepsy, cerebral small vessel disease, vascular cognitive impairment, glioma, spinal cord injury, etc, researchers are still looking for biomarkers with high sensitivity and specificity. The discovery of highly efficient biomarkers may partially replace some of the gold standards for invasive diagnosis, enabling a new era of non-invasive or low-invasive precision and individualized treatment.

This Research Topic aims to collect novel articles investigating the clinical application of biomarkers for neurovascular disorders, as well as innovation and developments in biomarkers in such disorders. We also encourage submissions probing the mechanisms underlying neurovascular disorders, including but not limited to, Alzheimer’s disease, ischemic stroke, cerebral small vessel disease, intracerebral hemorrhage, subarachnoid hemorrhage, venous sinus thrombosis, glioma, carotid disease, and vascular dementia.

Both Original Research and Review articles are welcomed.

Topics of interest include but are not limited to:

• Peripheral blood or cerebrospinal fluid biomarkers for neurovascular disorders
• Imaging markers for neurovascular disorders
• Research on pathogenic genes in neurovascular disorders
• Neurovascular disorders and disorders of diet, exercise, and intestinal flora
• Bioinformatics analysis of the prevention, treatment, and prognosis of neurovascular disorders

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Chinese Academy of Medical Sciences and Peking Union Medical College

University of Arizona

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Frontiers in Neurology

Neurological Biomarkers

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