Epigenetics is the study of how cells regulate gene expression without changing the DNA sequences. Epigenetic modifications can occur in DNA, RNA and at the protein level, with many types of epigenetic processes identified. Important epigenetic modifications include DNA methylation, m6A modification in RNA, post-transcriptional histone modifications such as methylation, acetylation, ubiquitination and phosphorylation. Unlike genetic changes, epigenetic modifications are reversible and could be viewed as a bridge between genotype and phenotype. During the past decades, there has been growing evidence that epigenetic regulation is very important to health and there are strong connections between dysregulated epigenetic modification and carcinogenesis. In addition, there are growing commercial interests in epigenetics, as more and more pharmaceutical companies are trying to identify potential therapeutic targets and new epigenetic diagnostic methods.
In this research topic, we aim to collect original research and review articles focusing on epigenetic modification regulation, identifying new epigenetic modification types and new epigenetic “writers”, “readers” and “erasers”. In addition, we also welcome manuscripts related to epigenetic regulation in carcinogenesis. We hope this research topic will lead to a better understanding of epigenetic modification mechanism and highlight the clinical significance of epigenetic drugs and diagnostics.
Areas of interest include but are not limited to the following aspects:
• Novel modifications of DNA, RNA and proteins
• Functional analysis of epigenetic tools (writers, readers and erasers)
• Epigenetic modifications in cellular homeostasis
• Epigenetic regulation in carcinogenesis
• Development of novel epigenetic biomarkers.
Epigenetics is the study of how cells regulate gene expression without changing the DNA sequences. Epigenetic modifications can occur in DNA, RNA and at the protein level, with many types of epigenetic processes identified. Important epigenetic modifications include DNA methylation, m6A modification in RNA, post-transcriptional histone modifications such as methylation, acetylation, ubiquitination and phosphorylation. Unlike genetic changes, epigenetic modifications are reversible and could be viewed as a bridge between genotype and phenotype. During the past decades, there has been growing evidence that epigenetic regulation is very important to health and there are strong connections between dysregulated epigenetic modification and carcinogenesis. In addition, there are growing commercial interests in epigenetics, as more and more pharmaceutical companies are trying to identify potential therapeutic targets and new epigenetic diagnostic methods.
In this research topic, we aim to collect original research and review articles focusing on epigenetic modification regulation, identifying new epigenetic modification types and new epigenetic “writers”, “readers” and “erasers”. In addition, we also welcome manuscripts related to epigenetic regulation in carcinogenesis. We hope this research topic will lead to a better understanding of epigenetic modification mechanism and highlight the clinical significance of epigenetic drugs and diagnostics.
Areas of interest include but are not limited to the following aspects:
• Novel modifications of DNA, RNA and proteins
• Functional analysis of epigenetic tools (writers, readers and erasers)
• Epigenetic modifications in cellular homeostasis
• Epigenetic regulation in carcinogenesis
• Development of novel epigenetic biomarkers.