Microbiota in Skin Inflammatory Diseases

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About this Research Topic

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Background

The skin is the largest organ of the body that protects from the external environment. The skin is also the home of fungi, viruses, and bacteria that compose the skin microbiota, which similar to the gut microbiota, educate the immune system to maintain homeostatic immunity. The host immune cells and microbiota interactions play important roles in tissue repair, wound healing, barrier function, and prevention of invasion of opportunistic pathogens. In addition, alterations in skin microbiota defined as dysbiosis can lead to several skin inflammatory conditions that are hard to treat. Gut dysbiosis can be linked to changes in the immune composition of the skin, leading to inflammatory disorders in the skin.

Studying the communication between microbiota and host cells including immune and epithelial cells is important to understand the mechanism of inflammatory skin diseases and to design better therapeutics. Despite the crucial role of the skin microbiota in regulating the host’s immunity and inflammation, how alterations in the composition of the microbiota influence the skin inflammatory disorders is not completely defined.

The goal of the current research topic is to compile the original research, reviews, and mini-reviews addressing the microbiota and host cells interactions that relate to skin inflammatory diseases and homeostatic immunity. The topic also covers the effect of gut microbiota in modulating skin immunity and inflammation. We welcome the submission articles covering, but not limited to the following subtopics:
- Effect of gut microbiota in modulating skin immunity and inflammation
- Defining the skin and gut microbiota of skin inflammatory diseases
- Epithelial and immune cell interactions with skin microbiota in modulating the skin immunity and inflammation
- Skin microbiota in wound healing, barrier function, and infection-induced skin inflammation
- Microbiota-induced chemokines in skin immunity and inflammation
- Inflammation tolerance and skin microbiota
- Opportunistic bacterial infection and dysbiosis

Keywords: Immune cells, Epithelial cells, Microbiota, bacteria, fungi, protozoan parasites, chemokines, Antimicrobials, Antibiotics, Gut, mice models, treatment strategies, Skin Inflammatory Disorders

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