The high mortality rate of patients in intensive care units (ICU) is a major public health concern. In addition to the traditional risk factors, the effects of endocrine abnormalities causing increased mortality in ICU patients cannot be ignored. Patients in the ICU are prone to endocrine metabolic abnormalities such as sepsis, shock and acute blood glucose elevation, which affect the short-term and long-term prognosis. Currently, sepsis is considered as a Pan-Endocrine Illness, causing changes in almost all functional hormonal axes including hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-thyroid axis and so on. Similarly, Shock induces neuroendocrine dysfunction and a flood of inflammatory mediators, causing metabolic and functional disturbances in the organism on multiple fronts. Abnormally elevated blood glucose is also a common endocrine alteration in critically ill patients, which increases cytokine and multi-organ function damage. Therefore, early identification of endocrine metabolic abnormalities in critically ill patients is of great importance for clinical management and prognosis of patients.
Given inadequate recognition of endocrine disorder in critical illness, the goal of this Research Topic is to promote recent advances in the field of abnormal endocrine metabolism in critical illness and clarify the relationship between endocrine metabolic abnormalities and critical illness, which will facilitate the development of precise therapeutic strategies for critical diseases.
Potential subtopics include but are not limited to the following:
• Identification of the risk factors for endocrine metabolic abnormalities and prediction of outcomes in critically ill patients
• Analysis of endocrine metabolism disorders caused by critical illnesses using multi-omics data
• Exploration of the underlying biological mechanisms of abnormal endocrine metabolism in critically ill patients
The high mortality rate of patients in intensive care units (ICU) is a major public health concern. In addition to the traditional risk factors, the effects of endocrine abnormalities causing increased mortality in ICU patients cannot be ignored. Patients in the ICU are prone to endocrine metabolic abnormalities such as sepsis, shock and acute blood glucose elevation, which affect the short-term and long-term prognosis. Currently, sepsis is considered as a Pan-Endocrine Illness, causing changes in almost all functional hormonal axes including hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-thyroid axis and so on. Similarly, Shock induces neuroendocrine dysfunction and a flood of inflammatory mediators, causing metabolic and functional disturbances in the organism on multiple fronts. Abnormally elevated blood glucose is also a common endocrine alteration in critically ill patients, which increases cytokine and multi-organ function damage. Therefore, early identification of endocrine metabolic abnormalities in critically ill patients is of great importance for clinical management and prognosis of patients.
Given inadequate recognition of endocrine disorder in critical illness, the goal of this Research Topic is to promote recent advances in the field of abnormal endocrine metabolism in critical illness and clarify the relationship between endocrine metabolic abnormalities and critical illness, which will facilitate the development of precise therapeutic strategies for critical diseases.
Potential subtopics include but are not limited to the following:
• Identification of the risk factors for endocrine metabolic abnormalities and prediction of outcomes in critically ill patients
• Analysis of endocrine metabolism disorders caused by critical illnesses using multi-omics data
• Exploration of the underlying biological mechanisms of abnormal endocrine metabolism in critically ill patients
