Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are two of the major types of chronic liver diseases in addition to being serious health and socioeconomic problems worldwide. Inflammatory processes play key roles in the pathogeneses of NAFLD and ALD, and continuous inflammation leads to the progression of nonalcoholic steatohepatitis (NASH) and alcoholic steatohepatitis (ASH), which further progress to liver cirrhosis and cancer. Thus, understanding the underlying inflammatory mechanisms of NAFLD and ALD and discovering novel therapeutic targets are imperative.
It is widely known that immune cells, especially the innate immune cells such as macorphages, neutrophils, and innate lymphoid cells, play diverse but essential roles in the inflammatory processes of NAFLD and ALD. Furthermore, the gut-liver axis is also involved in hepatic inflammation in these fatty liver diseases. Understanding the roles of immune cells in the liver and gut in NAFLD and ALD will be beneficial for proposing effective treatments.
This Research Topic aims not only to investigate the underlying inflammatory mechanisms during pathogenesis of NAFLD and ALD, but to reveal heterogeneity of immune cells in the liver and gut by utilizing advanced technologies, such as single-cell RNA sequencing. This Topic also aims to highlight new knowledge about immunometabolism, which has emerged as a major regulator of different immune cell types but has not been well investigated in NAFLD and ALD. Finally, research targeting the gut-liver axis to interfere in the immunological microenvironment in NAFLD and ALD is also of interest. This Topic will provide new insights into the basic and clinical research for treating NAFLD and ALD.
We welcome original research articles, reviews, opinion, perspectives, and systematic reviews, covering but not limited to the following themes:
• Investigation of the immunological mechanisms and new targets in NAFLD, ALD and their related diseases.
• Investigation on the heterogeneity of immune cells in NAFLD, ALD and their related diseases.
• Manipulation of immunometabolism in NAFLD, ALD and their related diseases.
• Targeting the gut-liver axis in NAFLD, ALD, and their related diseases.
• Translational studies of investigating and/or targeting immune cells or inflammatory processes in NAFLD, ALD, and their related diseases.
Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are two of the major types of chronic liver diseases in addition to being serious health and socioeconomic problems worldwide. Inflammatory processes play key roles in the pathogeneses of NAFLD and ALD, and continuous inflammation leads to the progression of nonalcoholic steatohepatitis (NASH) and alcoholic steatohepatitis (ASH), which further progress to liver cirrhosis and cancer. Thus, understanding the underlying inflammatory mechanisms of NAFLD and ALD and discovering novel therapeutic targets are imperative.
It is widely known that immune cells, especially the innate immune cells such as macorphages, neutrophils, and innate lymphoid cells, play diverse but essential roles in the inflammatory processes of NAFLD and ALD. Furthermore, the gut-liver axis is also involved in hepatic inflammation in these fatty liver diseases. Understanding the roles of immune cells in the liver and gut in NAFLD and ALD will be beneficial for proposing effective treatments.
This Research Topic aims not only to investigate the underlying inflammatory mechanisms during pathogenesis of NAFLD and ALD, but to reveal heterogeneity of immune cells in the liver and gut by utilizing advanced technologies, such as single-cell RNA sequencing. This Topic also aims to highlight new knowledge about immunometabolism, which has emerged as a major regulator of different immune cell types but has not been well investigated in NAFLD and ALD. Finally, research targeting the gut-liver axis to interfere in the immunological microenvironment in NAFLD and ALD is also of interest. This Topic will provide new insights into the basic and clinical research for treating NAFLD and ALD.
We welcome original research articles, reviews, opinion, perspectives, and systematic reviews, covering but not limited to the following themes:
• Investigation of the immunological mechanisms and new targets in NAFLD, ALD and their related diseases.
• Investigation on the heterogeneity of immune cells in NAFLD, ALD and their related diseases.
• Manipulation of immunometabolism in NAFLD, ALD and their related diseases.
• Targeting the gut-liver axis in NAFLD, ALD, and their related diseases.
• Translational studies of investigating and/or targeting immune cells or inflammatory processes in NAFLD, ALD, and their related diseases.