Despite their notorious toxicity, gaseous signaling molecules (GSMs), such as nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) have recently been of increasing interest due to their beneficial effects at low concentrations. These GSMs are particularly important for maintaining homeostasis and affecting different cellular processes, including apoptosis, proliferation, and cellular respiration. Moreover, their concentration changes depending on hormones concentration, and it is related to a variety of endocrine disorders, including diabetes, hypertension and cardiovascular diseases.
The underlying mechanisms through which GSMs concentration is regulated and how they extert their functions would be useful to develop drugs for treatment of these disorders. The current development of macromolecular nanocarriers, for instance, could provide a great tool for the safe and convenient delivery of GSMs.
In this article collection we welcome manuscripts focusing on GSMs signaling pathways and regulation. Themes of particular interest include but are not limited to:
- GSMs molecular mechanisms and signaling pathways in the endocrine system;
- Hormonal regulation by and of GSMs;
- New techniques for delivering GSMs to target proteins;
- New drugs targeting GSMs for treatment of endocrine disorders.
Despite their notorious toxicity, gaseous signaling molecules (GSMs), such as nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) have recently been of increasing interest due to their beneficial effects at low concentrations. These GSMs are particularly important for maintaining homeostasis and affecting different cellular processes, including apoptosis, proliferation, and cellular respiration. Moreover, their concentration changes depending on hormones concentration, and it is related to a variety of endocrine disorders, including diabetes, hypertension and cardiovascular diseases.
The underlying mechanisms through which GSMs concentration is regulated and how they extert their functions would be useful to develop drugs for treatment of these disorders. The current development of macromolecular nanocarriers, for instance, could provide a great tool for the safe and convenient delivery of GSMs.
In this article collection we welcome manuscripts focusing on GSMs signaling pathways and regulation. Themes of particular interest include but are not limited to:
- GSMs molecular mechanisms and signaling pathways in the endocrine system;
- Hormonal regulation by and of GSMs;
- New techniques for delivering GSMs to target proteins;
- New drugs targeting GSMs for treatment of endocrine disorders.
