The term chronic disease (CD) refers to physical health conditions that are long lasting, difficult to treat, and associated with disability. Many CDs are also associated with a chronic proinflammatory environment, related to inflammatory biomarkers and cytokines. However, advances in diagnosis, technology, and treatment of CDs in children and adolescents have allowed illnesses with historically poor prognoses to be successfully treated, thus reducing mortality and increasing survival. Consequently, a substantial number of children living with CDs receive medications that improve their conditions but cause adverse effects.
In the adult population, the presence of CD has been shown to increase the risk of developing obesity and other cardiometabolic and endocrine disorders. In the pediatric population, the frequency of CDs is similar to that in the adult population, so the presence of cardiometabolic and endocrine disorders is also similar. Additionally, when overweight/obesity coexists with CD, these rates increase significantly. The presence of chronic diseases, along with obesity, worsens proinflammatory conditions and results in an increased risk of cardiometabolic complications.
It is important to study the frequency of these alterations, the prognostic factors, and their relationship in pediatric populations. It is especially valuable for doctors caring for pediatric patients with CD to have the latest research in order to better treat their patients, given the extended length of time pediatric patients must live with these co-existing conditions.
This Research Topic will focus on the interplay and frequency of endocrine and cardiometabolic alterations in pediatric patients with chronic diseases. We are especially interested in translational work with a focus on prognostic factors, the impact on quality of life, and possible treatments. We welcome original research articles, reviews, mini reviews, clinical work, and perspectives related to the following areas:
• Frequency of cardiometabolic and endocrine disorders in pediatric patients with chronic diseases
• Prognostic factors of cardiometabolic and endocrine disorders in pediatric patients with chronic diseases
• Clinical intervention studies on cardiometabolic and endocrine disorders in pediatric patients with chronic diseases
• Impact of cardiometabolic and endocrinology disorders on quality of life in pediatric patients with chronic diseases
• Relationship between cardiometabolic and endocrine disorders and chronic diseases over an extended time in pediatric patients
• Long-term effects of the interplay between chronic diseases and obesity/overweight over time in pediatric populations
The term chronic disease (CD) refers to physical health conditions that are long lasting, difficult to treat, and associated with disability. Many CDs are also associated with a chronic proinflammatory environment, related to inflammatory biomarkers and cytokines. However, advances in diagnosis, technology, and treatment of CDs in children and adolescents have allowed illnesses with historically poor prognoses to be successfully treated, thus reducing mortality and increasing survival. Consequently, a substantial number of children living with CDs receive medications that improve their conditions but cause adverse effects.
In the adult population, the presence of CD has been shown to increase the risk of developing obesity and other cardiometabolic and endocrine disorders. In the pediatric population, the frequency of CDs is similar to that in the adult population, so the presence of cardiometabolic and endocrine disorders is also similar. Additionally, when overweight/obesity coexists with CD, these rates increase significantly. The presence of chronic diseases, along with obesity, worsens proinflammatory conditions and results in an increased risk of cardiometabolic complications.
It is important to study the frequency of these alterations, the prognostic factors, and their relationship in pediatric populations. It is especially valuable for doctors caring for pediatric patients with CD to have the latest research in order to better treat their patients, given the extended length of time pediatric patients must live with these co-existing conditions.
This Research Topic will focus on the interplay and frequency of endocrine and cardiometabolic alterations in pediatric patients with chronic diseases. We are especially interested in translational work with a focus on prognostic factors, the impact on quality of life, and possible treatments. We welcome original research articles, reviews, mini reviews, clinical work, and perspectives related to the following areas:
• Frequency of cardiometabolic and endocrine disorders in pediatric patients with chronic diseases
• Prognostic factors of cardiometabolic and endocrine disorders in pediatric patients with chronic diseases
• Clinical intervention studies on cardiometabolic and endocrine disorders in pediatric patients with chronic diseases
• Impact of cardiometabolic and endocrinology disorders on quality of life in pediatric patients with chronic diseases
• Relationship between cardiometabolic and endocrine disorders and chronic diseases over an extended time in pediatric patients
• Long-term effects of the interplay between chronic diseases and obesity/overweight over time in pediatric populations