Recent studies have revealed that various food components and nutrients affect immune responses which may bring health benefits. These food components or nutrients may enhance immune responses, leading to host defense against infection, or inhibit immune responses, suppressing allergy and inflammation. Dendritic cells (both conventional dendritic cells and plasmacytoid dendritic cells) are important targets in these cases, since they orchestrate various immune responses.
Although the effects of food components or nutrients on dendritic cells have been reported, the underlying mechanisms (e.g. recognition of food components, intracellular and intercellular signaling, contribution of intestinal microflora and their metabolites) have not been clearly described and further research is required.
In this research topic in vivo animal studies, in vitro systems and human studies are all welcome.
Various type of food components or nutrients, including probiotics, prebiotics, non-viable lactic acid bacteria, polysaccharides, vitamins, minerals, fatty acids, protein, peptides, amino acids and polyphenols, or extracts of food may be examined.
This research topic will cover (but is not limited to):
1) effects of food components on intestinal dendritic cells
2) intracellular signaling in dendritic cells after stimulation by food components
3) response of dendritic cells after ingestion of food or nutrients
4) Investigation of various immune responses related to dendric cells such as responses of T cell subsets, antibody production, immune tolerance, inflammation and host defense may be included
5) The involvement of intestinal microbiota and their metabolites may also be addressed
Recent studies have revealed that various food components and nutrients affect immune responses which may bring health benefits. These food components or nutrients may enhance immune responses, leading to host defense against infection, or inhibit immune responses, suppressing allergy and inflammation. Dendritic cells (both conventional dendritic cells and plasmacytoid dendritic cells) are important targets in these cases, since they orchestrate various immune responses.
Although the effects of food components or nutrients on dendritic cells have been reported, the underlying mechanisms (e.g. recognition of food components, intracellular and intercellular signaling, contribution of intestinal microflora and their metabolites) have not been clearly described and further research is required.
In this research topic in vivo animal studies, in vitro systems and human studies are all welcome.
Various type of food components or nutrients, including probiotics, prebiotics, non-viable lactic acid bacteria, polysaccharides, vitamins, minerals, fatty acids, protein, peptides, amino acids and polyphenols, or extracts of food may be examined.
This research topic will cover (but is not limited to):
1) effects of food components on intestinal dendritic cells
2) intracellular signaling in dendritic cells after stimulation by food components
3) response of dendritic cells after ingestion of food or nutrients
4) Investigation of various immune responses related to dendric cells such as responses of T cell subsets, antibody production, immune tolerance, inflammation and host defense may be included
5) The involvement of intestinal microbiota and their metabolites may also be addressed
