One of the most devastating diseases worldwide today is cancer, affecting millions of people each year. Despite the development of various therapies, cancer remains the leading cause of death. Consumption of fruits, vegetables, and grains have been strongly associated with reduced risk of cancer. The biologically active constituents present in fruits, vegetables and grains are collectively termed as polyphenols, many of which provide desirable health benefits beyond nutrition. Cancer protective effects have been reported in individuals consuming high quantities of fruits and vegetables compared to who consume less. Similarly, a plethora of information is available implicating dietary agents in prevention of cancers of the skin, prostate, breast and lung. While the anticancer properties of several common dietary polyphenols like EGCG, resveratrol, genistein and quercetin have been well established, the underlying molecular mechanisms of their antiproliferative effects are not completely understood.
Dietary polyphenols have been shown to affect the overall process of carcinogenesis by several mechanisms and their effects may depend on tissue or cell type and may differ at high and low doses. Therefore, further studies are required to deepen our understanding of polyphenol and their anti-cancer and chemopreventive properties. Furthermore, polyphenols may be recommended to prevent cancer and even to improve existing cancer treatment strategies. It is imperative to carry out studies to elucidate mechanisms responsible for anticancer properties of such compounds. The acquired knowledge could be used to design novel anticancer drugs, which selectively kill cancer cells while sparing normal cells.
This Research Topic will focus on understanding the connection between polyphenols and cancer, highlighting recent advances in our understanding of the anti-cancer and chemopreventive properties of polyphenols. We welcome articles in the form of Original Research, Brief Research Reports, Reviews and Mini Reviews covering, but not limited to the following (or similar) topics:
• Effects of polyphenol consumption on cancer prevention and treatment;
• Molecular studies concerning the anti-cancer mechanisms of polyphenols in vitro and in vivo
• Molecular studies concerning the chemopreventive mechanisms of polyphenols in vitro and in vivo;
• Studies on polyphenol enriched foods improving cancer chemoprevention and survival;
One of the most devastating diseases worldwide today is cancer, affecting millions of people each year. Despite the development of various therapies, cancer remains the leading cause of death. Consumption of fruits, vegetables, and grains have been strongly associated with reduced risk of cancer. The biologically active constituents present in fruits, vegetables and grains are collectively termed as polyphenols, many of which provide desirable health benefits beyond nutrition. Cancer protective effects have been reported in individuals consuming high quantities of fruits and vegetables compared to who consume less. Similarly, a plethora of information is available implicating dietary agents in prevention of cancers of the skin, prostate, breast and lung. While the anticancer properties of several common dietary polyphenols like EGCG, resveratrol, genistein and quercetin have been well established, the underlying molecular mechanisms of their antiproliferative effects are not completely understood.
Dietary polyphenols have been shown to affect the overall process of carcinogenesis by several mechanisms and their effects may depend on tissue or cell type and may differ at high and low doses. Therefore, further studies are required to deepen our understanding of polyphenol and their anti-cancer and chemopreventive properties. Furthermore, polyphenols may be recommended to prevent cancer and even to improve existing cancer treatment strategies. It is imperative to carry out studies to elucidate mechanisms responsible for anticancer properties of such compounds. The acquired knowledge could be used to design novel anticancer drugs, which selectively kill cancer cells while sparing normal cells.
This Research Topic will focus on understanding the connection between polyphenols and cancer, highlighting recent advances in our understanding of the anti-cancer and chemopreventive properties of polyphenols. We welcome articles in the form of Original Research, Brief Research Reports, Reviews and Mini Reviews covering, but not limited to the following (or similar) topics:
• Effects of polyphenol consumption on cancer prevention and treatment;
• Molecular studies concerning the anti-cancer mechanisms of polyphenols in vitro and in vivo
• Molecular studies concerning the chemopreventive mechanisms of polyphenols in vitro and in vivo;
• Studies on polyphenol enriched foods improving cancer chemoprevention and survival;