This Research Topic is part of the series on
Vascular Function and Aging. Other titles in this series are:
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Vascular Function and Aging: a Focus on Oxidative StressAs we age, the vasculature in our body goes toward morphological, structural and functional changes, even in healthy individuals. These mechanisms are at the basis of many cardiovascular and age-related diseases and can be altered and exacerbated by underlying pathologies or pathophysiological disorders such as hypertension, obesity or other metabolic disorders.
Hypertension, insulin resistance, obesity and atherosclerosis accelerate the vascular morphological and functional alterations expected at advanced ages resulting in the so-called early vascular ageing. Major physiological processes are deeply involved in this process. These include inflammatory, metabolic, dietary or oxidative stress factors. In this sense, important work has been carried out on dietary studies, nutraceuticals and reactive oxygen and nitrogen species. Additionally, in the last years new mechanisms have been proposed as underlying the accelerated vascular ageing. These include steroid receptors, adipose tissue derived factors like DPP4, connective tissue factors like MMP2, Pin1, SIRT1, Klotho, relaxin, transglutaminase 2 or SGLT2. This Research Topic welcomes basic, translational, computational, and applied research focusing on how vascular function changes during aging and its interaction with obesity, hypertension and other metabolic disorders. The underlying mechanisms of vascular aging and vascular integrity are also of great interest to this collection.
Potential areas of interest may include, but are not limited to:
- The role of diet and aerobic exercise in vascular ageing.
- Nutraceuticals in the prevention of early vascular ageing.
- Inflammation and vascular ageing.
- The role of reactive oxygen and nitrogen species in accelerated vascular ageing.
- Novel mechanisms in vascular ageing (sex hormone and mineralocorticoid receptors, DPP4, MMP2, Pin1, SIRT1, Klotho, relaxin, transglutaminase 2, SGLT2, etc).
- Microbiome and microbiota during aging: effects on endothelial function and vascular integrity;
- The molecular basis of vascular stiffness: calcification, vascular remodeling and inflammation.
We welcome submissions of different article types to this collection, especially reviews, mini-reviews, and original research papers.
Even though abstract submission is not mandatory, we encourage all interested researchers to submit an abstract before submitting their manuscript. Abstracts do not have to coincide with the final abstract of the manuscripts.