Inflammation participates importantly in host defenses against infectious agents and injury, but it also contributes to the pathophysiology of many chronic diseases. Interactions of cells in the innate immune system, adaptive immune system, and inflammatory mediators orchestrate aspects of the acute and chronic inflammation that underlie diseases of many organs. A coordinated series of common effector mechanisms of inflammation contribute to tissue injury, oxidative stress, remodeling of the extracellular matrix, angiogenesis, and fibrosis in diverse target tissues. ROS produced by phagocytes participates in host defense response and acts as a signal molecule and mediator of inflammation. The environmental level of ROS is important for cell homeostasis. Too much ROS and insufficient antioxidants can lead to inflammatory tissue damage. Therefore, cellular antioxidant mechanisms play a vital role in establishing this complex balance, but how ROS works physiologically and how they lead to inflammation and tissue damage are still unknown. Mastery of the inflammatory response should aid the development of novel strategies to predict disease susceptibility, target and monitor therapies, and ultimately develop new approaches to the prevention and treatment of inflammatory and immune diseases.
The purpose of this study is to study the relationship between inflammation and immunomodulation in immune diseases and to explore the pathogenesis and targeted treatment of the disease. Understanding the pathological characteristics of the disease can provide potential new drug targets for inflammatory immune diseases. Therefore, this topic hopes to include screening new drugs from new targets, constructing new drug carrier systems, and understanding the interaction between oxidative stress and inflammation, and their role in tissue damage.
We welcome original articles, comments, and opinions in the subtopics of interest, including but not limited to the following subtopics:
•Study on the pathogenesis and new targets of inflammatory and immune diseases
•Discover new drugs or construct new drug carriers to treat inflammatory and immune diseases
•Molecular mechanism of oxidative stress-mediated signal transduction in inflammation
•The interaction between ROS production and inflammation
•Oxidative stress and tissue damage
•The relationship between oxidative stress and the immune system
Inflammation participates importantly in host defenses against infectious agents and injury, but it also contributes to the pathophysiology of many chronic diseases. Interactions of cells in the innate immune system, adaptive immune system, and inflammatory mediators orchestrate aspects of the acute and chronic inflammation that underlie diseases of many organs. A coordinated series of common effector mechanisms of inflammation contribute to tissue injury, oxidative stress, remodeling of the extracellular matrix, angiogenesis, and fibrosis in diverse target tissues. ROS produced by phagocytes participates in host defense response and acts as a signal molecule and mediator of inflammation. The environmental level of ROS is important for cell homeostasis. Too much ROS and insufficient antioxidants can lead to inflammatory tissue damage. Therefore, cellular antioxidant mechanisms play a vital role in establishing this complex balance, but how ROS works physiologically and how they lead to inflammation and tissue damage are still unknown. Mastery of the inflammatory response should aid the development of novel strategies to predict disease susceptibility, target and monitor therapies, and ultimately develop new approaches to the prevention and treatment of inflammatory and immune diseases.
The purpose of this study is to study the relationship between inflammation and immunomodulation in immune diseases and to explore the pathogenesis and targeted treatment of the disease. Understanding the pathological characteristics of the disease can provide potential new drug targets for inflammatory immune diseases. Therefore, this topic hopes to include screening new drugs from new targets, constructing new drug carrier systems, and understanding the interaction between oxidative stress and inflammation, and their role in tissue damage.
We welcome original articles, comments, and opinions in the subtopics of interest, including but not limited to the following subtopics:
•Study on the pathogenesis and new targets of inflammatory and immune diseases
•Discover new drugs or construct new drug carriers to treat inflammatory and immune diseases
•Molecular mechanism of oxidative stress-mediated signal transduction in inflammation
•The interaction between ROS production and inflammation
•Oxidative stress and tissue damage
•The relationship between oxidative stress and the immune system
