Plants and microbes synthesize several secondary metabolites (SMs) for their growth, environmental adaptation and defense. Many of these SMs have bioactivities that are exploited in a wide variety of applications ranging from medicinal, cosmeceutical and nutraceutical interests. Some of these secondary metabolites are also exploited for large-scale production due to demand and their economic feasibility. Since high bioactive metabolites may have low abundance in their native habitats, alternative modes of production and scaling-up have been investigated and good progress has been made using plant and microbial platforms. Plant cell cultures, in addition to serving as valuable conservation systems, have become the candidates of choice for the production of SMs as they perform posttranslational modifications and can be manipulated using genomics techniques. Methods of metabolic engineering and synthetic biology have now become useful for engineering metabolic and biosynthetic pathways in plant and microbial systems as eco-friendly alternative approaches.
The proposed Research Topic will comprehensively present the current research on expressions of heterologous production of high valued metabolites in plants and microbes. Submitted articles will also cover new concepts and their corresponding applications. This Research Topic will consist of well-written articles by eminent authors supported by immaculate and fitting illustrations. This will go a long way toward acquainting the reader with a much wider scope of knowledge on the production of high-value bioactive metabolites in plants and microbes while taking cognizance of the important contributions of biotechnology and effective integration of relevant interdisciplinary research. Reanalyzing this perspective could reveal a world of knowledge encompassing valuable potential sources of prized metabolites and bright hope for future applications. Furthermore, it is the authors’ unbiased approach to guide the reader through fundamental principles, mechanistic views, and product formulation of bioactive natural products. The related subjects of modern plant and microbial biotechnology, mainly transgenic systems, metabolic engineering, heterologous metabolite expression, synthetic biology and nanobiotechnology, are strongly interlinked and interwoven subjects that will be included in the proposed Research Topic.
Plants and microbes synthesize several secondary metabolites (SMs) for their growth, environmental adaptation and defense. Many of these SMs have bioactivities that are exploited in a wide variety of applications ranging from medicinal, cosmeceutical and nutraceutical interests. Some of these secondary metabolites are also exploited for large-scale production due to demand and their economic feasibility. Since high bioactive metabolites may have low abundance in their native habitats, alternative modes of production and scaling-up have been investigated and good progress has been made using plant and microbial platforms. Plant cell cultures, in addition to serving as valuable conservation systems, have become the candidates of choice for the production of SMs as they perform posttranslational modifications and can be manipulated using genomics techniques. Methods of metabolic engineering and synthetic biology have now become useful for engineering metabolic and biosynthetic pathways in plant and microbial systems as eco-friendly alternative approaches.
The proposed Research Topic will comprehensively present the current research on expressions of heterologous production of high valued metabolites in plants and microbes. Submitted articles will also cover new concepts and their corresponding applications. This Research Topic will consist of well-written articles by eminent authors supported by immaculate and fitting illustrations. This will go a long way toward acquainting the reader with a much wider scope of knowledge on the production of high-value bioactive metabolites in plants and microbes while taking cognizance of the important contributions of biotechnology and effective integration of relevant interdisciplinary research. Reanalyzing this perspective could reveal a world of knowledge encompassing valuable potential sources of prized metabolites and bright hope for future applications. Furthermore, it is the authors’ unbiased approach to guide the reader through fundamental principles, mechanistic views, and product formulation of bioactive natural products. The related subjects of modern plant and microbial biotechnology, mainly transgenic systems, metabolic engineering, heterologous metabolite expression, synthetic biology and nanobiotechnology, are strongly interlinked and interwoven subjects that will be included in the proposed Research Topic.