As low- and middle-income countries are experiencing a rapid transition in epidemics, the burden has shifted from infectious diseases to non-communicable diseases, all ages of disease management had become a global focus. In recent years, exposure of the fetus or infant to a harmful environment has been found to increase the risk of developing non-communicable diseases in childhood. Obesity, developmental deviation, and unhealthy lifestyle behaviors are also associated with metabolic diseases, cancers, immunodeficiency diseases, and cognitive impairment diseases in childhood. Evolving precision medicine including pediatric genomics has led to a progression in the discovery of causative genes and improved diagnosis of childhood diseases, especially rare diseases in children, through emerging state-of-the-art technologies such as whole-exome sequencing, whole-genome sequencing and single-cell sequencing. Furthermore, a better understanding of the genetic basis of the disease drives into more accurate prognosis, management, monitoring and genetic counselling; stimulates research into precise diagnosis and treatment based on pathogenic mechanisms; and enables the provision of better support.
The precision diagnosis and treatments have been more recognized as they improve the prognosis of children. This Research Topic focuses on precision medicine of non-communicable diseases in children, to discover and validate the novel biomarkers in the disease diagnosis and development, the applications of targeted treatment (biological agents, enzyme replacement therapy, etc.), the behavioral intervention or psychological guidance among the children, and so on, to establish uniform diagnostic protocols for relevant diseases with novel biomarkers, and to emphasize all the benefits, potentials, as well as limitations and disadvantages of studied targeted treatment, compared with the current treatment protocol.
We welcome submissions of original research articles, novel reviews, and meta-analyses on precision medicine of non-communicable diseases in children. With the advancement of genetics, bioinformatics and medications, pediatric disease research continues to evolve. Topics of interest include but are not limited to the following aspects.
• Discovery and validation of novel biomarkers or tests in the accurate diagnosis and evaluation of non-communicable diseases in children.
• Applications or reviews of targeted treatment in pediatric diseases, such as biological agents, enzyme replacement therapy, gene therapy, etc.
• Behavioral intervention and psychological guidance of Autism Spectrum Disorder, or other accidental injury etc.
As low- and middle-income countries are experiencing a rapid transition in epidemics, the burden has shifted from infectious diseases to non-communicable diseases, all ages of disease management had become a global focus. In recent years, exposure of the fetus or infant to a harmful environment has been found to increase the risk of developing non-communicable diseases in childhood. Obesity, developmental deviation, and unhealthy lifestyle behaviors are also associated with metabolic diseases, cancers, immunodeficiency diseases, and cognitive impairment diseases in childhood. Evolving precision medicine including pediatric genomics has led to a progression in the discovery of causative genes and improved diagnosis of childhood diseases, especially rare diseases in children, through emerging state-of-the-art technologies such as whole-exome sequencing, whole-genome sequencing and single-cell sequencing. Furthermore, a better understanding of the genetic basis of the disease drives into more accurate prognosis, management, monitoring and genetic counselling; stimulates research into precise diagnosis and treatment based on pathogenic mechanisms; and enables the provision of better support.
The precision diagnosis and treatments have been more recognized as they improve the prognosis of children. This Research Topic focuses on precision medicine of non-communicable diseases in children, to discover and validate the novel biomarkers in the disease diagnosis and development, the applications of targeted treatment (biological agents, enzyme replacement therapy, etc.), the behavioral intervention or psychological guidance among the children, and so on, to establish uniform diagnostic protocols for relevant diseases with novel biomarkers, and to emphasize all the benefits, potentials, as well as limitations and disadvantages of studied targeted treatment, compared with the current treatment protocol.
We welcome submissions of original research articles, novel reviews, and meta-analyses on precision medicine of non-communicable diseases in children. With the advancement of genetics, bioinformatics and medications, pediatric disease research continues to evolve. Topics of interest include but are not limited to the following aspects.
• Discovery and validation of novel biomarkers or tests in the accurate diagnosis and evaluation of non-communicable diseases in children.
• Applications or reviews of targeted treatment in pediatric diseases, such as biological agents, enzyme replacement therapy, gene therapy, etc.
• Behavioral intervention and psychological guidance of Autism Spectrum Disorder, or other accidental injury etc.
