Active and passive changes in the mechanical environment have been shown to affect the heart's electrical activity and this is referred to as mechanoelectric coupling (MEC). Stretch in the heart can cause changes to the electrical activity through MEC, and it has even been suggested that this feedback plays a role in the mechanical initiation of arrhythmias and fibrillation.
This Research Topic welcomes basic, translational, clinical, and applied research that improves our understanding of mechanoelectrical coupling and arrhythmias. Potential areas of interest may include, but are not limited to:
- stretch induced modification of calcium signaling
- mechano-energetic role in arrhythmias
- force sensing by Piezo, TRP and other stretch activated channels in the heart
- cardiomyocyte-fibroblast interaction
- role of stretch in acquired and inherited heart disease
- mathematical modelling approaches to stretch and arrhythmias
- myocardial mechanical and electrical heterogeneities
- mechanoelectrical interaction in cardiac pacing and CRT
We welcome the submission of different article types to this collection, especially reviews, mini-reviews, and original research papers. For a complete list of article types that can be considered in the Cardiac Electrophysiology section, please follow
this link. Even though abstract submission is not mandatory, we encourage all interested researchers to submit an abstract before submitting their manuscript. Abstracts do not have to coincide with the final abstract of the manuscripts.
Active and passive changes in the mechanical environment have been shown to affect the heart's electrical activity and this is referred to as mechanoelectric coupling (MEC). Stretch in the heart can cause changes to the electrical activity through MEC, and it has even been suggested that this feedback plays a role in the mechanical initiation of arrhythmias and fibrillation.
This Research Topic welcomes basic, translational, clinical, and applied research that improves our understanding of mechanoelectrical coupling and arrhythmias. Potential areas of interest may include, but are not limited to:
- stretch induced modification of calcium signaling
- mechano-energetic role in arrhythmias
- force sensing by Piezo, TRP and other stretch activated channels in the heart
- cardiomyocyte-fibroblast interaction
- role of stretch in acquired and inherited heart disease
- mathematical modelling approaches to stretch and arrhythmias
- myocardial mechanical and electrical heterogeneities
- mechanoelectrical interaction in cardiac pacing and CRT
We welcome the submission of different article types to this collection, especially reviews, mini-reviews, and original research papers. For a complete list of article types that can be considered in the Cardiac Electrophysiology section, please follow
this link. Even though abstract submission is not mandatory, we encourage all interested researchers to submit an abstract before submitting their manuscript. Abstracts do not have to coincide with the final abstract of the manuscripts.
