Atherosclerosis is the pathological basis of many ischemic diseases including acute myocardial infarction, ischemic stroke, and lower limb ischemia. Despite previous study have confirmed inflammatory response and lipid metabolism disorders are the key causes of atherosclerosis progression, the underlying mechanism remains unclear.
Recently, a large number of studies have revealed that some novel inflammatory factors and bioactive lipids, such as IL-37, IL-38, ceramides and lysoglycerophospholipids, are closely related to the occurrence and progression of atherosclerosis. Furthermore, there are evidence suggested that some novel bioactive lipids and inflammatory factors are independently correlated with the criminal plaque characteristics and long-term prognosis in patients with acute myocardial infarction. But to the best of our knowledge, the role and underlying mechanism of these novel inflammatory factors and bioactive lipids in atherosclerosis remains unclear.
Since endovascular imaging (optical coherence tomography and endovascular ultrasound) can assess the morphology, characteristics and stability of atherosclerotic plaques in vivo, endovascular imaging has been widely used in cardiovascular intervention and clinical research in recent years. Thus, intravascular imaging can be used to evaluate in vivo the role of novel inflammatory factors and bioactive lipids on atherosclerotic plaque progression.
This Research Topic aims to identify novel inflammatory factors and bioactive lipids to diagnosis and predict cardiovascular outcome in atherosclerosis related diseases, and to explore the effect and the underlying mechanism of novel inflammatory factors and bioactive lipids in the development of atherosclerosis. Original research and review articles are welcome.
Specific themes we would like contributors to address include, but are not limited to:
- Study on novel inflammatory factors and bioactive lipids in the diagnosis of atherosclerotic related diseases
- Application of novel inflammatory factors and bioactive lipids in the construction of cardiovascular disease risk stratification
- Study on the relationship between novel inflammatory factors and bioactive lipids and plaque morphology, characteristics and progression by endovascular imaging
- In vivo and in vitro experiments on the role and mechanism of novel inflammatory factors and bioactive lipids in the development of atherosclerosis
- Study on discovering new inflammatory factors and bioactive lipids in patients with atherosclerosis by using lipidomics and proteomics
Atherosclerosis is the pathological basis of many ischemic diseases including acute myocardial infarction, ischemic stroke, and lower limb ischemia. Despite previous study have confirmed inflammatory response and lipid metabolism disorders are the key causes of atherosclerosis progression, the underlying mechanism remains unclear.
Recently, a large number of studies have revealed that some novel inflammatory factors and bioactive lipids, such as IL-37, IL-38, ceramides and lysoglycerophospholipids, are closely related to the occurrence and progression of atherosclerosis. Furthermore, there are evidence suggested that some novel bioactive lipids and inflammatory factors are independently correlated with the criminal plaque characteristics and long-term prognosis in patients with acute myocardial infarction. But to the best of our knowledge, the role and underlying mechanism of these novel inflammatory factors and bioactive lipids in atherosclerosis remains unclear.
Since endovascular imaging (optical coherence tomography and endovascular ultrasound) can assess the morphology, characteristics and stability of atherosclerotic plaques in vivo, endovascular imaging has been widely used in cardiovascular intervention and clinical research in recent years. Thus, intravascular imaging can be used to evaluate in vivo the role of novel inflammatory factors and bioactive lipids on atherosclerotic plaque progression.
This Research Topic aims to identify novel inflammatory factors and bioactive lipids to diagnosis and predict cardiovascular outcome in atherosclerosis related diseases, and to explore the effect and the underlying mechanism of novel inflammatory factors and bioactive lipids in the development of atherosclerosis. Original research and review articles are welcome.
Specific themes we would like contributors to address include, but are not limited to:
- Study on novel inflammatory factors and bioactive lipids in the diagnosis of atherosclerotic related diseases
- Application of novel inflammatory factors and bioactive lipids in the construction of cardiovascular disease risk stratification
- Study on the relationship between novel inflammatory factors and bioactive lipids and plaque morphology, characteristics and progression by endovascular imaging
- In vivo and in vitro experiments on the role and mechanism of novel inflammatory factors and bioactive lipids in the development of atherosclerosis
- Study on discovering new inflammatory factors and bioactive lipids in patients with atherosclerosis by using lipidomics and proteomics