Transforming growth factor-ß (TGF-ß) plays a critical role in regulating T cell biology. TGF-ß has a pleiotropic effects on T cells. TGF-ß is a critical cytokine driving T cell tolerance by directly suppressing effector T cell activation but also by promoting suppressive T cell function. Besides, paradoxically, TGF-ß is also a potent inducer of inflammatory T cells such as Th17 and Th9 T cells as well promotes T cell tissue residency which have been associated with immunosurveillance in periphery. This multifaceted effect of TGF-ß on T cell biology that at first glance would appear antagonistic is puzzling, although it concords to maintaining the overall homeostasis.
This pleiotropic effect of TGF-ß on T cells may account for a cellular context, which means it may differ depending on the cell type and the state of activation or differentiation of the cells. The intricate signaling cascades of TGF-ß contribute also greatly contribute to its diverse biological functions, adding additional complexity. This Research Topic seeks reviews or original research articles that decorticate TGF-ß effects on T cell biology and their physiological as well as pathological consequences.
We welcome original research, review, mini-review, and perspective articles on the following areas:
• Novel insights into different actions of TGF-ß in governing T cell biology (subset determination, activation, differentiation, localization as well as metabolism)
• Unraveling the distinct effects of each TGF-ß signaling pathway on T cell biology (at functional, proteomic, transcriptomic, and epigenetic levels)
• The clinical importance of TGF-ß signaling in T cells in pathology and homeostasis (Cancer, inflammation, etc.)
Transforming growth factor-ß (TGF-ß) plays a critical role in regulating T cell biology. TGF-ß has a pleiotropic effects on T cells. TGF-ß is a critical cytokine driving T cell tolerance by directly suppressing effector T cell activation but also by promoting suppressive T cell function. Besides, paradoxically, TGF-ß is also a potent inducer of inflammatory T cells such as Th17 and Th9 T cells as well promotes T cell tissue residency which have been associated with immunosurveillance in periphery. This multifaceted effect of TGF-ß on T cell biology that at first glance would appear antagonistic is puzzling, although it concords to maintaining the overall homeostasis.
This pleiotropic effect of TGF-ß on T cells may account for a cellular context, which means it may differ depending on the cell type and the state of activation or differentiation of the cells. The intricate signaling cascades of TGF-ß contribute also greatly contribute to its diverse biological functions, adding additional complexity. This Research Topic seeks reviews or original research articles that decorticate TGF-ß effects on T cell biology and their physiological as well as pathological consequences.
We welcome original research, review, mini-review, and perspective articles on the following areas:
• Novel insights into different actions of TGF-ß in governing T cell biology (subset determination, activation, differentiation, localization as well as metabolism)
• Unraveling the distinct effects of each TGF-ß signaling pathway on T cell biology (at functional, proteomic, transcriptomic, and epigenetic levels)
• The clinical importance of TGF-ß signaling in T cells in pathology and homeostasis (Cancer, inflammation, etc.)