Squamous cell carcinoma (SCC) is one of the epithelial cancers, which is originated from the upper layers of skin epidermis. The high incidence of squamous cell carcinoma (SCC) is observed in many countries, and the most common sites to be affected are vagina, uterine cervix, larynx, hypopharynx and oropharynx. The causes of SCC are varied and complex, however, very few studies of human papillomavirus (HPV) responses SCC. As a major type, cervical carcinoma remains one of the most common cancers in females. CC patients' survival has barely improved despite the continuous development of treatment options, which may put a huge financial strain on patients and society. Hence, it is necessary to character the molecular mechanisms behind CC. When it comes to head and neck cancer, head and neck squamous cell carcinoma (HNSCC) ranks sixth among all cancer types in the world. HNSCC are frequently locally advanced at diagnosis due to its insidious onset, resulting poor prognosis and a low survival rate in patients with HNSCC. Identification of disease subtypes are urgently needed for precision therapy of HNSCC.
Human papillomavirus (HPV) is composed of a circular genome and a double-stranded DNA molecule, and is proven to be a crucial factor of cervical carcinoma. HPV viruses are highly specific for mucosal squamous epithelium. According to the genomic sequence information, two HPV types (16 and 18) lead to the most HPV-related cancers, such as cervical cancers and partial head and neck cancers. It is worth noting that eighty percent of people would get an HPV infection at some point in their lives. Hence, deciphering the detailed molecular mechanisms behind human papillomavirus-related squamous cell carcinoma are urgently necessary.
This Research Topic focuses on the relationship between human papillomavirus and squamous cell carcinoma, which aims to elucidate the specific molecular landscapes and detailed molecular mechanisms that underpin these. We hope this Research Topic provides new and personalized strategies for the treatment of human papillomavirus-related squamous cell carcinoma and guide treatment from the perspective of HPV infection. We welcome the submission of Original Studies, Reviews, Hypotheses and Theories, Opinions, and Clinical Trial articles, focusing on but not limited to the following topics:
1. Mechanisms of HPV affecting the development of squamous cell carcinoma.
2. The relationship and interaction between HPV infection and squamous cell carcinoma.
3. The specific role of HPV in the prognosis of squamous cell carcinoma.
4. Novel therapeutic measures against HPV-related squamous cell carcinoma.
5. Unique molecular landscapes of human papillomavirus-related squamous cell carcinoma.
Please note:
Those consisting solely of bioinformatic investigation of publicly available genomic / transcriptomic data without experimental or in situ validation to support conclusions.
Those focused on proteomic and metabolomic investigation.
Squamous cell carcinoma (SCC) is one of the epithelial cancers, which is originated from the upper layers of skin epidermis. The high incidence of squamous cell carcinoma (SCC) is observed in many countries, and the most common sites to be affected are vagina, uterine cervix, larynx, hypopharynx and oropharynx. The causes of SCC are varied and complex, however, very few studies of human papillomavirus (HPV) responses SCC. As a major type, cervical carcinoma remains one of the most common cancers in females. CC patients' survival has barely improved despite the continuous development of treatment options, which may put a huge financial strain on patients and society. Hence, it is necessary to character the molecular mechanisms behind CC. When it comes to head and neck cancer, head and neck squamous cell carcinoma (HNSCC) ranks sixth among all cancer types in the world. HNSCC are frequently locally advanced at diagnosis due to its insidious onset, resulting poor prognosis and a low survival rate in patients with HNSCC. Identification of disease subtypes are urgently needed for precision therapy of HNSCC.
Human papillomavirus (HPV) is composed of a circular genome and a double-stranded DNA molecule, and is proven to be a crucial factor of cervical carcinoma. HPV viruses are highly specific for mucosal squamous epithelium. According to the genomic sequence information, two HPV types (16 and 18) lead to the most HPV-related cancers, such as cervical cancers and partial head and neck cancers. It is worth noting that eighty percent of people would get an HPV infection at some point in their lives. Hence, deciphering the detailed molecular mechanisms behind human papillomavirus-related squamous cell carcinoma are urgently necessary.
This Research Topic focuses on the relationship between human papillomavirus and squamous cell carcinoma, which aims to elucidate the specific molecular landscapes and detailed molecular mechanisms that underpin these. We hope this Research Topic provides new and personalized strategies for the treatment of human papillomavirus-related squamous cell carcinoma and guide treatment from the perspective of HPV infection. We welcome the submission of Original Studies, Reviews, Hypotheses and Theories, Opinions, and Clinical Trial articles, focusing on but not limited to the following topics:
1. Mechanisms of HPV affecting the development of squamous cell carcinoma.
2. The relationship and interaction between HPV infection and squamous cell carcinoma.
3. The specific role of HPV in the prognosis of squamous cell carcinoma.
4. Novel therapeutic measures against HPV-related squamous cell carcinoma.
5. Unique molecular landscapes of human papillomavirus-related squamous cell carcinoma.
Please note:
Those consisting solely of bioinformatic investigation of publicly available genomic / transcriptomic data without experimental or in situ validation to support conclusions.
Those focused on proteomic and metabolomic investigation.