In healthy skeleton, its structural and mechanical properties are maintained by a concerted action of osteoblasts and osteoclasts. These cells are responsible for bone remodeling, which is a well-organized and fine regulated mechanism, involving local and systemic factors (growth factors, cytokines, hormones). Alterations of bone remodeling impact skeletal integrity, leading to excessive or impaired bone resorption as well as reduced or disorganized bone formation.
The analysis of cellular and molecular signaling underlying bone diseases, including tumor and genetic disorders, allows the identification of new pathways also involved in bone physiological processes.
These results underlined how investigating bone diseases may represent a way to find new determinants of bone physiology and its better understanding may lead to the identification of new therapeutic approaches.
This Research Topic will focus on the identification of genetic and molecular determinants involved in both bone health and diseases.
The identification of new targets is pivotal in order to better understand the complex bone environment and all its characteristics.
The analysis of in vivo bone experimental systems such as the characterization of the skeletal phenotype in animal models also represents an aim of this Research Topic.
Furthermore, the ability to manipulate the identified pathways with well-characterized or new compounds would describe and identify new therapeutic approaches for bone homeostasis.
In this Research Topic, we aim to collect articles that contribute to the innovative achievements in bone health and diseases. We welcome the submission of Original research, Method, Opinion articles, Reviews and Mini-Reviews.
Main topics include but are not limited to:
• New developments in signaling pathways of osteoclasts, osteoblasts, osteocytes, and mesenchymal stem cells;
• New insights into genetic bone diseases;
• Novel mechanisms involved in bone remodeling activity and in bone diseases (including pediatric, cancer, and rare diseases);
• Identification of new therapeutic approaches to restore bone physiology;
• Development of new drugs to treat bone diseases;
• Description of new animal models for bone diseases;
• In vivo characterization of animal models’ skeleton phenotype.
In healthy skeleton, its structural and mechanical properties are maintained by a concerted action of osteoblasts and osteoclasts. These cells are responsible for bone remodeling, which is a well-organized and fine regulated mechanism, involving local and systemic factors (growth factors, cytokines, hormones). Alterations of bone remodeling impact skeletal integrity, leading to excessive or impaired bone resorption as well as reduced or disorganized bone formation.
The analysis of cellular and molecular signaling underlying bone diseases, including tumor and genetic disorders, allows the identification of new pathways also involved in bone physiological processes.
These results underlined how investigating bone diseases may represent a way to find new determinants of bone physiology and its better understanding may lead to the identification of new therapeutic approaches.
This Research Topic will focus on the identification of genetic and molecular determinants involved in both bone health and diseases.
The identification of new targets is pivotal in order to better understand the complex bone environment and all its characteristics.
The analysis of in vivo bone experimental systems such as the characterization of the skeletal phenotype in animal models also represents an aim of this Research Topic.
Furthermore, the ability to manipulate the identified pathways with well-characterized or new compounds would describe and identify new therapeutic approaches for bone homeostasis.
In this Research Topic, we aim to collect articles that contribute to the innovative achievements in bone health and diseases. We welcome the submission of Original research, Method, Opinion articles, Reviews and Mini-Reviews.
Main topics include but are not limited to:
• New developments in signaling pathways of osteoclasts, osteoblasts, osteocytes, and mesenchymal stem cells;
• New insights into genetic bone diseases;
• Novel mechanisms involved in bone remodeling activity and in bone diseases (including pediatric, cancer, and rare diseases);
• Identification of new therapeutic approaches to restore bone physiology;
• Development of new drugs to treat bone diseases;
• Description of new animal models for bone diseases;
• In vivo characterization of animal models’ skeleton phenotype.
