In multicellular organisms, cell-to-cell communication forms the basis for coordinated cellular activities. The signaling events behind cell-to-cell communication are mediated by various processes, including cell junctions, adhesion contacts, or secretory factors. The secretory factors, including cytokines, chemokines, non-coding RNA, and exosomes, mediate intercellular communication and interaction in almost all biological systems, especially in the immune system. Communication between immune cells or somatic cells is essential for immune responses. The secretome of immune cells is regulated by the pathological state and highlights the roles of these secretory factors in Immune disorders. Numerous studies have implicated that cytokines exert important effects with regard to various inflammatory diseases. Recent reports about exosome and non-coding RNA in immune disorders also attract increasing attention. However, the mechanisms governing the biogenesis, release, and uptake of new secretory factors in the immune system are unknown. This Research Topic sets out to elucidate the role of new secretory factors or the new mechanism of classic secretory factors in regulating immune responses and disorders.
The goal of this Research Topic is to provide a forum to advance research on the contribution of secretory factors to the genesis and development of immune disorders and explore the secretory factors-oriented biomarkers or pharmacological interventions. We welcome manuscripts from the following subtopics:
1) Discovery of new secretory factors in the immune system
2) Molecular mechanism for regulating expression and secretion of secretory factors in regulating immune response and disorders.
3) The role of new secretory factors or new mechanisms of classic secretory factors in regulating immune response and disorders (e.g., Infectious or Inflammatory Disease/Tumor Immunology, etc.)
4) Secretory factors as biomarkers in immune disease diagnosis
5) Clinical trials about secretory factors against immune-related diseases
In multicellular organisms, cell-to-cell communication forms the basis for coordinated cellular activities. The signaling events behind cell-to-cell communication are mediated by various processes, including cell junctions, adhesion contacts, or secretory factors. The secretory factors, including cytokines, chemokines, non-coding RNA, and exosomes, mediate intercellular communication and interaction in almost all biological systems, especially in the immune system. Communication between immune cells or somatic cells is essential for immune responses. The secretome of immune cells is regulated by the pathological state and highlights the roles of these secretory factors in Immune disorders. Numerous studies have implicated that cytokines exert important effects with regard to various inflammatory diseases. Recent reports about exosome and non-coding RNA in immune disorders also attract increasing attention. However, the mechanisms governing the biogenesis, release, and uptake of new secretory factors in the immune system are unknown. This Research Topic sets out to elucidate the role of new secretory factors or the new mechanism of classic secretory factors in regulating immune responses and disorders.
The goal of this Research Topic is to provide a forum to advance research on the contribution of secretory factors to the genesis and development of immune disorders and explore the secretory factors-oriented biomarkers or pharmacological interventions. We welcome manuscripts from the following subtopics:
1) Discovery of new secretory factors in the immune system
2) Molecular mechanism for regulating expression and secretion of secretory factors in regulating immune response and disorders.
3) The role of new secretory factors or new mechanisms of classic secretory factors in regulating immune response and disorders (e.g., Infectious or Inflammatory Disease/Tumor Immunology, etc.)
4) Secretory factors as biomarkers in immune disease diagnosis
5) Clinical trials about secretory factors against immune-related diseases