Several viruses circulate in the environment, establishing constant interactions with potential host cells. Likewise, hosts expend energy generating immune responses to avoid viral infections and virus-induced damage.
In the last few years, the advances in new omic-technologies, the use of metagenomics, and predictive models applied to ecology and integrating multiscale data have allowed us to improve our knowledge about virus-host interactions in the context of multiple viral influences. The evolution and transmission dynamics of pathogens is a complex process that depends on the interaction between pathogens, hosts, vectors, as well as biotic, abiotic, socio-economic, cultural, and ecological factors. Researchers need to consider such complex interacting factors for a better understanding of host-virus interactions in the context of mono- or co-infections.
In this Research Topic, we intend to bring more clarity to answer some old questions on host-virus interactions supported by new advances and technologies in the area of virus research. Some key questions are: What are the virus-virus interactions at the host molecular and cellular levels? What are the key points of the early stage of infection to understand the immune long-term consequences in the host? How does previous exposure to a virus modulate the immune response to a simultaneous or sequential exposure to another viral species? Further, how do environmental factors such as temperature, humidity, and others, contribute to establishing a viral infection?
We welcome the submission of multidisciplinary works connecting immunology, virology, molecular and cell biology, structural biology, ecology, systems biology, among other fields that cover, but are not limited to, the following subtopics:
1) Cross-immunity - The role of adaptive immunity in driving virus interference that alters the population dynamics of other viruses
2) Early immune response - PRRs activation of intracellular signaling cascades, induction of cytokines and antiviral genes
3) Epigenetic - The miRNA co-activations and RNA-binding proteins with virus
4) Mechanisms of immune-microbe interactions
5) Systems biology of infectious diseases
6) Environment-host interactions in viral infections
Several viruses circulate in the environment, establishing constant interactions with potential host cells. Likewise, hosts expend energy generating immune responses to avoid viral infections and virus-induced damage.
In the last few years, the advances in new omic-technologies, the use of metagenomics, and predictive models applied to ecology and integrating multiscale data have allowed us to improve our knowledge about virus-host interactions in the context of multiple viral influences. The evolution and transmission dynamics of pathogens is a complex process that depends on the interaction between pathogens, hosts, vectors, as well as biotic, abiotic, socio-economic, cultural, and ecological factors. Researchers need to consider such complex interacting factors for a better understanding of host-virus interactions in the context of mono- or co-infections.
In this Research Topic, we intend to bring more clarity to answer some old questions on host-virus interactions supported by new advances and technologies in the area of virus research. Some key questions are: What are the virus-virus interactions at the host molecular and cellular levels? What are the key points of the early stage of infection to understand the immune long-term consequences in the host? How does previous exposure to a virus modulate the immune response to a simultaneous or sequential exposure to another viral species? Further, how do environmental factors such as temperature, humidity, and others, contribute to establishing a viral infection?
We welcome the submission of multidisciplinary works connecting immunology, virology, molecular and cell biology, structural biology, ecology, systems biology, among other fields that cover, but are not limited to, the following subtopics:
1) Cross-immunity - The role of adaptive immunity in driving virus interference that alters the population dynamics of other viruses
2) Early immune response - PRRs activation of intracellular signaling cascades, induction of cytokines and antiviral genes
3) Epigenetic - The miRNA co-activations and RNA-binding proteins with virus
4) Mechanisms of immune-microbe interactions
5) Systems biology of infectious diseases
6) Environment-host interactions in viral infections
