There has been a growing appreciation for the beneficial roles of innate immune cells during CNS repair and regeneration. Studies have shown that in addition to their prototypical function of responding to infection and injury, these cells also promote various activities involved in repair and regeneration, e.g., releasing trophic factors, phagocytosis, lipid metabolism, etc. Careful regulation of innate immune cells and activation of specific phenotypes are important during disease processes, and dysregulation of these cells can have deleterious consequences in the CNS, such as demyelination and neurodegeneration.
The underlying regulatory processes promoting unique functional subtypes of CNS innate immune cells are not well established, nor are the effector mechanisms underlying the effects of these cells on CNS injury and repair. Therefore, the goal of this research topic is to better understand the cellular and molecular mechanisms serving innate immune cell fate and function during CNS inflammation and repair/regeneration, which will have a significant implication in developing treatments for various neurological (multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, etc.) and psychiatric (mood disorders, anxiety, etc.) disorders.
The scope of the research topic will broadly address the role of CNS innate immune cells, such as microglia and CNS-infiltrating macrophages, during the regenerative and reparative processes in CNS as well as their involvement in neurodegeneration and demyelination. We are requesting manuscripts that cover, but are not limited to, these topics:
1. Detailed molecular mechanism of microglial and macrophage inflammatory processes during demyelination and neurodegeneration.
2. Elucidating signaling pathways involved in immunomodulation of innate immune cells.
3. Transcriptional profile of innate immune cells during inflammatory processes.
4. Novel therapeutic target for immunomodulation of innate immune cells.
5. Understanding the intricate interactions among innate immune cells, astrocytes, neurons, and oligodendrocytes during remyelination/demyelination, neuroprotection/neurotoxicity, and neurogenesis/neurodegeneration.
There has been a growing appreciation for the beneficial roles of innate immune cells during CNS repair and regeneration. Studies have shown that in addition to their prototypical function of responding to infection and injury, these cells also promote various activities involved in repair and regeneration, e.g., releasing trophic factors, phagocytosis, lipid metabolism, etc. Careful regulation of innate immune cells and activation of specific phenotypes are important during disease processes, and dysregulation of these cells can have deleterious consequences in the CNS, such as demyelination and neurodegeneration.
The underlying regulatory processes promoting unique functional subtypes of CNS innate immune cells are not well established, nor are the effector mechanisms underlying the effects of these cells on CNS injury and repair. Therefore, the goal of this research topic is to better understand the cellular and molecular mechanisms serving innate immune cell fate and function during CNS inflammation and repair/regeneration, which will have a significant implication in developing treatments for various neurological (multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, etc.) and psychiatric (mood disorders, anxiety, etc.) disorders.
The scope of the research topic will broadly address the role of CNS innate immune cells, such as microglia and CNS-infiltrating macrophages, during the regenerative and reparative processes in CNS as well as their involvement in neurodegeneration and demyelination. We are requesting manuscripts that cover, but are not limited to, these topics:
1. Detailed molecular mechanism of microglial and macrophage inflammatory processes during demyelination and neurodegeneration.
2. Elucidating signaling pathways involved in immunomodulation of innate immune cells.
3. Transcriptional profile of innate immune cells during inflammatory processes.
4. Novel therapeutic target for immunomodulation of innate immune cells.
5. Understanding the intricate interactions among innate immune cells, astrocytes, neurons, and oligodendrocytes during remyelination/demyelination, neuroprotection/neurotoxicity, and neurogenesis/neurodegeneration.
