Cancer metastasis is a deadly disease that results in organ failure which is associated with alterations/defects in the immune system. Patients with metastatic diseases often experience resistance to chemotherapy and/or targeted therapeutics. It remains unknown how immune cell compositions are altered in association with disease progression and metastasis. Further, it is poorly understood whether therapeutically induced anti-tumor immune responses may be related to treatment resistance.
This Research Topic aims to gain a deeper understanding of the mechanisms that alter the intra-tumor and peripheral immune cell compositions/patterns during metastasis. It will also investigate whether there is a functional association between therapeutically induced anti-tumor immune responses and the development of treatment resistance during metastasis. We will also cover the functional relationship between immune surveillance and intra-tumor vs. peripheral immune cell compositions/patterns during anti-cancer therapy and the development of treatment resistance in solid tumor metastasis.
We welcome the submission of Original Research, Systematic Review, Review, Mini Review, Clinical Trial, Opinion, and Perspective articles covering, but not limited to, the following subtopics:
• Clinical and preclinical studies to unravel the range of intra-tumor and systemic immune perturbations that occur during cancer metastasis in solid tumors.
• Therapeutically induced anti-tumor immune responses and contribution of intra-tumor and peripheral immune cells to treatment resistance in metastasis.
• Utility of advanced technologies such as single-cell sequencing, and machine learning algorithms to identify immune cell biomarkers in diagnostics and prognosis of metastatic cancer and response to therapy.
• Functional relationship between immune surveillance and intra-tumor vs. peripheral immune cell compositions/patterns during anti-cancer therapy and development of treatment resistance in solid tumor metastasis.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Cancer metastasis is a deadly disease that results in organ failure which is associated with alterations/defects in the immune system. Patients with metastatic diseases often experience resistance to chemotherapy and/or targeted therapeutics. It remains unknown how immune cell compositions are altered in association with disease progression and metastasis. Further, it is poorly understood whether therapeutically induced anti-tumor immune responses may be related to treatment resistance.
This Research Topic aims to gain a deeper understanding of the mechanisms that alter the intra-tumor and peripheral immune cell compositions/patterns during metastasis. It will also investigate whether there is a functional association between therapeutically induced anti-tumor immune responses and the development of treatment resistance during metastasis. We will also cover the functional relationship between immune surveillance and intra-tumor vs. peripheral immune cell compositions/patterns during anti-cancer therapy and the development of treatment resistance in solid tumor metastasis.
We welcome the submission of Original Research, Systematic Review, Review, Mini Review, Clinical Trial, Opinion, and Perspective articles covering, but not limited to, the following subtopics:
• Clinical and preclinical studies to unravel the range of intra-tumor and systemic immune perturbations that occur during cancer metastasis in solid tumors.
• Therapeutically induced anti-tumor immune responses and contribution of intra-tumor and peripheral immune cells to treatment resistance in metastasis.
• Utility of advanced technologies such as single-cell sequencing, and machine learning algorithms to identify immune cell biomarkers in diagnostics and prognosis of metastatic cancer and response to therapy.
• Functional relationship between immune surveillance and intra-tumor vs. peripheral immune cell compositions/patterns during anti-cancer therapy and development of treatment resistance in solid tumor metastasis.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.