Infertility is a prevalent condition affecting an estimated 70 million people globally. Male factor contributes to 50% of the issues defined as male infertility. Male infertility, such as azoospermia, oligozoospermia, teratozoospermia, asthenozoospermia, necrospermia and pyospermia, is a multi-factorial syndrome encompassing a wide variety of disorders. Substantial evidence indicates that most of them are complex disorders with genetic risk factors contributing to their development and progression. The expanding awareness of different genes, mRNAs, and non-coding RNAs that play a role in spermatogenesis, spermiogenesis and the onset of the development of male infertility, will help better manage these conditions. However, more causative genes and non-coding RNAs related to male infertility, as well as the mechanisms are awaited to be discovered.
This Research Topic aims to collect articles that identify the novel components involved in the etiology, pathogenesis, diagnosis and therapy of male infertility. These components could include different gene variants, various types of RNA (mRNAs and non-coding RNAs), and aneuploidy. We hope that the application of novel molecular genetic techniques or disease models provide a valuable basis for a comprehensive understanding of the etiology and pathogenesis of male infertility, facilitating the development of targeted diagnostic and therapeutic strategies.
We welcome Original Research, Brief Research Reports, Reviews, and Methods papers focused on integrating different approaches to identify the genetic factors in male infertility. These could include but are not limited to:
(1) Identification of novel male infertility pathogenic genes, novel variants of known genes, non-coding RNAs, metabolites and genetic mechanisms involved in etiology and pathogenesis of male infertility.
(2) Identification of potential diagnostic markers and therapeutic targets for male infertility
Infertility is a prevalent condition affecting an estimated 70 million people globally. Male factor contributes to 50% of the issues defined as male infertility. Male infertility, such as azoospermia, oligozoospermia, teratozoospermia, asthenozoospermia, necrospermia and pyospermia, is a multi-factorial syndrome encompassing a wide variety of disorders. Substantial evidence indicates that most of them are complex disorders with genetic risk factors contributing to their development and progression. The expanding awareness of different genes, mRNAs, and non-coding RNAs that play a role in spermatogenesis, spermiogenesis and the onset of the development of male infertility, will help better manage these conditions. However, more causative genes and non-coding RNAs related to male infertility, as well as the mechanisms are awaited to be discovered.
This Research Topic aims to collect articles that identify the novel components involved in the etiology, pathogenesis, diagnosis and therapy of male infertility. These components could include different gene variants, various types of RNA (mRNAs and non-coding RNAs), and aneuploidy. We hope that the application of novel molecular genetic techniques or disease models provide a valuable basis for a comprehensive understanding of the etiology and pathogenesis of male infertility, facilitating the development of targeted diagnostic and therapeutic strategies.
We welcome Original Research, Brief Research Reports, Reviews, and Methods papers focused on integrating different approaches to identify the genetic factors in male infertility. These could include but are not limited to:
(1) Identification of novel male infertility pathogenic genes, novel variants of known genes, non-coding RNAs, metabolites and genetic mechanisms involved in etiology and pathogenesis of male infertility.
(2) Identification of potential diagnostic markers and therapeutic targets for male infertility
