The obesity pandemic represents a catastrophic problem for public health in developed and developing countries. Genetic factors and obesogenic environment, characterized by inexpensive high-calorie foods and nonphysical entertainments, promote adipose tissue accumulation and consequently the development of diabetes, cardiovascular diseases and cancer. Adipose tissue hyperplasia and above all hypertrophy cause an alteration of secretory function of adipocytes leading to chronic low-grade inflammation and insulin resistance.
Adipose tissue derived-factors, from adipokines to inflammatory mediators and microRNA, not only have an autocrine action but affect the physiology of a variety of tissues regulating several functions, including appetite and energy expenditure, angiogenesis and cardiometabolic processes, neuroinflammation and cancer progression.
Accumulating data highlight how different dietary patterns alter adipose tissue secretome aggravating or counteracting obesity-induced damages. The relationship between nutrition and adipose tissue secretome have emphasized the potential therapeutical role of diet to recover, partially or completely, healthy state.
In this topic we would discuss the link between adipose tissue derived-factors and nutrition focusing our attention on 1) mechanism of action of different molecules secreted by adipose tissue; 2) diet role on modulation adipose secretome in physiological and pathological conditions. We encourage submissions of Original Research, Reviews, Mini-Reviews, Opinions and Perspective Articles covering, but not limited to, the following topics:
1. Identification and characterization of novel adipose tissue derived-factors and their mechanisms of action
2. Different adipose tissue compartments-Different adipose secretory profiles
3. Crosstalk between peripheral tissues and adipose secretome
4. Possible crosstalk between adipokines, breastfeeding and infant growth
5. Adipose tissues senescence: alteration of endocrinological function
6. Different diets-different adipose secretome
7. Crosstalk between cardiometabolic pathologies, adipose secretome and nutrition
8. Crosstalk between cancer, adipose secretome and nutrition
The obesity pandemic represents a catastrophic problem for public health in developed and developing countries. Genetic factors and obesogenic environment, characterized by inexpensive high-calorie foods and nonphysical entertainments, promote adipose tissue accumulation and consequently the development of diabetes, cardiovascular diseases and cancer. Adipose tissue hyperplasia and above all hypertrophy cause an alteration of secretory function of adipocytes leading to chronic low-grade inflammation and insulin resistance.
Adipose tissue derived-factors, from adipokines to inflammatory mediators and microRNA, not only have an autocrine action but affect the physiology of a variety of tissues regulating several functions, including appetite and energy expenditure, angiogenesis and cardiometabolic processes, neuroinflammation and cancer progression.
Accumulating data highlight how different dietary patterns alter adipose tissue secretome aggravating or counteracting obesity-induced damages. The relationship between nutrition and adipose tissue secretome have emphasized the potential therapeutical role of diet to recover, partially or completely, healthy state.
In this topic we would discuss the link between adipose tissue derived-factors and nutrition focusing our attention on 1) mechanism of action of different molecules secreted by adipose tissue; 2) diet role on modulation adipose secretome in physiological and pathological conditions. We encourage submissions of Original Research, Reviews, Mini-Reviews, Opinions and Perspective Articles covering, but not limited to, the following topics:
1. Identification and characterization of novel adipose tissue derived-factors and their mechanisms of action
2. Different adipose tissue compartments-Different adipose secretory profiles
3. Crosstalk between peripheral tissues and adipose secretome
4. Possible crosstalk between adipokines, breastfeeding and infant growth
5. Adipose tissues senescence: alteration of endocrinological function
6. Different diets-different adipose secretome
7. Crosstalk between cardiometabolic pathologies, adipose secretome and nutrition
8. Crosstalk between cancer, adipose secretome and nutrition