With the development of biology and medicine, diseases have been recognized at the cellular and even molecular levels. These findings provide the opportunities for accurate diagnosis and therapy yet raise new requirements on reagents. Smart reagents, including functional dyes, fluorescent sensors, delivery systems, small molecule drugs, etc., with targeting ability towards specific organelles or organs, are becoming one of the most popular categories of fine chemicals. They are essential material foundations for accurate fluorescence imaging, drug delivery, chemotherapy, etc. Thus, the development and application strategy of novel reagents with specific targeting ability is of great importance and research interest.
Targeted therapies can be driven at three levels: small molecules based on chemical modification, such as organelle targeted fluorescent probes; nanoparticles, such as lipid-like nanoparticles for mRNA delivery; cells-based delivery strategies, such as CAR-T therapy. These strategies are fit for different diagnosis and therapies of diseases. Current efforts are spent on improving their targeting specificity, stability, and biocompatibility. Further combination of three targeting strategies may take full advantage of all. The aim of this research topic is to gather the design and application of smart reagents for accurate diagnosis and therapies up to date and explore their potential clinical use.
In this research topic, we welcome Original Research, Review, Mini Review, and Perspective articles on themes including, but not limited to the development and application of:
• Functional fluorescence reagents (sensors, trackers, etc.)
• Targeted drugs (chemo drugs, photosensitizers, etc.)
• Targeted deliver platform (nanoparticles, artificial vector, etc.)
• Therapeutic strategies based on cells (innate immunocytes, blood cells, etc.)
With the development of biology and medicine, diseases have been recognized at the cellular and even molecular levels. These findings provide the opportunities for accurate diagnosis and therapy yet raise new requirements on reagents. Smart reagents, including functional dyes, fluorescent sensors, delivery systems, small molecule drugs, etc., with targeting ability towards specific organelles or organs, are becoming one of the most popular categories of fine chemicals. They are essential material foundations for accurate fluorescence imaging, drug delivery, chemotherapy, etc. Thus, the development and application strategy of novel reagents with specific targeting ability is of great importance and research interest.
Targeted therapies can be driven at three levels: small molecules based on chemical modification, such as organelle targeted fluorescent probes; nanoparticles, such as lipid-like nanoparticles for mRNA delivery; cells-based delivery strategies, such as CAR-T therapy. These strategies are fit for different diagnosis and therapies of diseases. Current efforts are spent on improving their targeting specificity, stability, and biocompatibility. Further combination of three targeting strategies may take full advantage of all. The aim of this research topic is to gather the design and application of smart reagents for accurate diagnosis and therapies up to date and explore their potential clinical use.
In this research topic, we welcome Original Research, Review, Mini Review, and Perspective articles on themes including, but not limited to the development and application of:
• Functional fluorescence reagents (sensors, trackers, etc.)
• Targeted drugs (chemo drugs, photosensitizers, etc.)
• Targeted deliver platform (nanoparticles, artificial vector, etc.)
• Therapeutic strategies based on cells (innate immunocytes, blood cells, etc.)
