In recent years, bioactive nanomaterials, which can elicit biological responses upon interacting with proteins, cells, or tissues in vivo, have attracted considerable research interest from the viewpoint of fundamental research and practical applications in the biomedical field. Compared with traditional biomaterials, the significant characteristic of bioactive nanomaterials is their diverse bioactivities, such as the capability of stimulating cell adhesion and proliferation, mimicking the bio-matrix for tissue regeneration, recognizing specific proteins and/or cells for biomimetics, releasing bioactive ions or molecules, excellent catalytic activities, and targeted drug delivery. With these marvelous properties, bioactive nanomaterials show great potential in the diagnosis and treatment of major chronic diseases including malignant tumors, bacterial infection, diabetes mellitus, neurodegenerative disorder, cardiovascular disease, and so on.
Despite great progress achieved in the development of advanced bioactive nanomaterials for the diagnosis and treatment of diseases, there are still lots of issues remaining to be addressed. Firstly, the therapeutic efficacy is usually not satisfactory due to the complexity of biological systems. Therefore, new strategies to improve the selectivity and efficiency in targeting and biodistribution at the organ and system levels are highly desired. Secondly, the majority of currently developed bioactive nanomaterials exhibit only one bioactivity, however, the biological system is a multifunctional synergistic entirety, designing multi-bioactive nanomaterials would be useful for fundamental studies and clinical applications. Moreover, biodegradable bioactive nanomaterials are needed to reduce the potential of cumulative toxicity to the normal tissues. In addition, few efforts have been dedicated to combining diagnostic and therapeutic functions into a single bioactive nanomaterial for major chronic diseases.
We welcome Original Research, Review, Mini Review, and Perspective articles on themes including, but not limited to:
• Design and preparation of new bioactive nanomaterials to enhance the therapeutic efficacy of major chronic diseases (e.g. cancer, inflammation, diabetes, Alzheimer’s disease, cardiovascular disease, etc.)
• Novel bioactive nanomaterials for diagnosis of major chronic diseases.
• Multifunctional bioactive nanomaterials used in combination therapies.
• Toxicology studies on bioactive nanomaterials.
In recent years, bioactive nanomaterials, which can elicit biological responses upon interacting with proteins, cells, or tissues in vivo, have attracted considerable research interest from the viewpoint of fundamental research and practical applications in the biomedical field. Compared with traditional biomaterials, the significant characteristic of bioactive nanomaterials is their diverse bioactivities, such as the capability of stimulating cell adhesion and proliferation, mimicking the bio-matrix for tissue regeneration, recognizing specific proteins and/or cells for biomimetics, releasing bioactive ions or molecules, excellent catalytic activities, and targeted drug delivery. With these marvelous properties, bioactive nanomaterials show great potential in the diagnosis and treatment of major chronic diseases including malignant tumors, bacterial infection, diabetes mellitus, neurodegenerative disorder, cardiovascular disease, and so on.
Despite great progress achieved in the development of advanced bioactive nanomaterials for the diagnosis and treatment of diseases, there are still lots of issues remaining to be addressed. Firstly, the therapeutic efficacy is usually not satisfactory due to the complexity of biological systems. Therefore, new strategies to improve the selectivity and efficiency in targeting and biodistribution at the organ and system levels are highly desired. Secondly, the majority of currently developed bioactive nanomaterials exhibit only one bioactivity, however, the biological system is a multifunctional synergistic entirety, designing multi-bioactive nanomaterials would be useful for fundamental studies and clinical applications. Moreover, biodegradable bioactive nanomaterials are needed to reduce the potential of cumulative toxicity to the normal tissues. In addition, few efforts have been dedicated to combining diagnostic and therapeutic functions into a single bioactive nanomaterial for major chronic diseases.
We welcome Original Research, Review, Mini Review, and Perspective articles on themes including, but not limited to:
• Design and preparation of new bioactive nanomaterials to enhance the therapeutic efficacy of major chronic diseases (e.g. cancer, inflammation, diabetes, Alzheimer’s disease, cardiovascular disease, etc.)
• Novel bioactive nanomaterials for diagnosis of major chronic diseases.
• Multifunctional bioactive nanomaterials used in combination therapies.
• Toxicology studies on bioactive nanomaterials.
