Ovarian cancer is one of the most common malignancies amongst women and is often diagnosed at an advanced stage due to a lack of efficient screening methods. Epigenetic processes - which include DNA methylation, RNA modification, chromatin remodeling, genomic imprinting, histone modifications, and processes influenced by non-coding RNAs - have been demonstrated to play a key role in the tumorigenesis of ovarian cancer. For example, at least 35 miRNAs have been associated with the risk of progression or relapse, and expression levels of some miRNAs have been shown to modulate the responsiveness of ovarian cancer cells to chemotherapy. LncRNAs have also been shown to play a role in the pathogenesis of ovarian cancer and drug resistance, and recently a signature comprising six lncRNAs has been correlated with ovarian cancer recurrence.
Ongoing research is investigating the role of epigenetic processes in ovarian cancer, as well as the possibility of leveraging epigenetic processes to improve ovarian cancer treatment and ultimately outcomes for patients. This collection aims to collate research on the following:
● The role and impact of epigenetic mechanisms in the tumorigenesis and progression of ovarian cancer
● The role of epigenetic processes in therapeutic resistance in ovarian cancer
● New strategies or tools for the diagnosis and monitoring of ovarian cancer which incorporate epigenetic factors
● New ovarian cancer treatment approaches targeting or incorporating epigenetic processes
Please note: manuscripts that are solely based on bioinformatics or computational analysis of public databases without validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Ovarian cancer is one of the most common malignancies amongst women and is often diagnosed at an advanced stage due to a lack of efficient screening methods. Epigenetic processes - which include DNA methylation, RNA modification, chromatin remodeling, genomic imprinting, histone modifications, and processes influenced by non-coding RNAs - have been demonstrated to play a key role in the tumorigenesis of ovarian cancer. For example, at least 35 miRNAs have been associated with the risk of progression or relapse, and expression levels of some miRNAs have been shown to modulate the responsiveness of ovarian cancer cells to chemotherapy. LncRNAs have also been shown to play a role in the pathogenesis of ovarian cancer and drug resistance, and recently a signature comprising six lncRNAs has been correlated with ovarian cancer recurrence.
Ongoing research is investigating the role of epigenetic processes in ovarian cancer, as well as the possibility of leveraging epigenetic processes to improve ovarian cancer treatment and ultimately outcomes for patients. This collection aims to collate research on the following:
● The role and impact of epigenetic mechanisms in the tumorigenesis and progression of ovarian cancer
● The role of epigenetic processes in therapeutic resistance in ovarian cancer
● New strategies or tools for the diagnosis and monitoring of ovarian cancer which incorporate epigenetic factors
● New ovarian cancer treatment approaches targeting or incorporating epigenetic processes
Please note: manuscripts that are solely based on bioinformatics or computational analysis of public databases without validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.