A multi-objective full-parameter optimization particle swarm optimization (MOFOPSO) algorithm is proposed in this paper to overcome the drawbacks of poor accuracy, low efficiency, and instability of the existing algorithms in the inverse kinematics(IK) solution of the manipulator. In designing the multi-objective function, the proposed algorithm considers the factors such as position, posture, and joint. To improve PSO, the proposed algorithm comprehensively analyzes all factors affecting the global and local searching abilities. Based on this, the initial population is designed following the localized uniform distribution method. Meanwhile, the inertia weight, asynchronous learning factor, and time factor are respectively designed by introducing the iteration factor. Finally, this paper tests the performance of MOFOPSO with three typical functions to obtain a better inverse kinematics solution of the 6-DOF manipulator. Also, six other algorithms are taken for performance comparison. The experimental results indicate that the proposed method not only ensures the stability of the manipulator but also achieves high accuracy and efficiency in solving the inverse kinematics of the 6-DOF manipulator.