With the help of biotechnological methods, it is now possible to manipulate plant metabolism by altering enzyme activity. This has enabled the development of plants that are more resistant to biotic and abiotic stress, with improved nutritional quality and extended shelf life. Plants can also be used to produce highly valuable phytochemicals, substances that have biopharmaceutical and therapeutic potential. Plant genetic engineering generates commercially valuable biomaterials, in which the whole plant, certain plant parts or plant cell cultures are utilized to produce cytokines, blood proteins, hormones, antibodies, etc. Modern plant biotechnology calls for integrating bioprocesses and cellular engineering principles to maximize the yield of these high-value phytochemicals.
Plant bio-factories are biotechnological platforms based on plant cell and organ cultures, allowing the natural metabolic machinery of plants to be harnessed for bioconversion of phytochemicals. However, few plant bio-factories have been successfully implemented at an industrial level to date. This Research Topic investigates the latest methods and technologies used to develop high-yield plant cell bio-factories, including mathematical model-based bioprocess optimization, computational fluid dynamics, and assisted bioreactor design. Application of rational approaches including model-assisted metabolic engineering, the design of novel bioreactors and scale-up criteria specific to plant cell cultivation is also important, as well as designing novel elicitation strategies that exploit plant-microbe interaction, and the use of adaptive laboratory evolution and random mutations.
This Research Topic welcomes all research on the following:
• Plant metabolic engineering
• Metabolic flux analysis in plant cells
• Effect of plant-endophyte interaction on plant secondary metabolism
• Bioreactor cultivation of plant cells
• Model assisted plant cell based process optimization
• Scale-up of plant cell cultivations
• High-yielding plant cell line development without genetic modifications
With the help of biotechnological methods, it is now possible to manipulate plant metabolism by altering enzyme activity. This has enabled the development of plants that are more resistant to biotic and abiotic stress, with improved nutritional quality and extended shelf life. Plants can also be used to produce highly valuable phytochemicals, substances that have biopharmaceutical and therapeutic potential. Plant genetic engineering generates commercially valuable biomaterials, in which the whole plant, certain plant parts or plant cell cultures are utilized to produce cytokines, blood proteins, hormones, antibodies, etc. Modern plant biotechnology calls for integrating bioprocesses and cellular engineering principles to maximize the yield of these high-value phytochemicals.
Plant bio-factories are biotechnological platforms based on plant cell and organ cultures, allowing the natural metabolic machinery of plants to be harnessed for bioconversion of phytochemicals. However, few plant bio-factories have been successfully implemented at an industrial level to date. This Research Topic investigates the latest methods and technologies used to develop high-yield plant cell bio-factories, including mathematical model-based bioprocess optimization, computational fluid dynamics, and assisted bioreactor design. Application of rational approaches including model-assisted metabolic engineering, the design of novel bioreactors and scale-up criteria specific to plant cell cultivation is also important, as well as designing novel elicitation strategies that exploit plant-microbe interaction, and the use of adaptive laboratory evolution and random mutations.
This Research Topic welcomes all research on the following:
• Plant metabolic engineering
• Metabolic flux analysis in plant cells
• Effect of plant-endophyte interaction on plant secondary metabolism
• Bioreactor cultivation of plant cells
• Model assisted plant cell based process optimization
• Scale-up of plant cell cultivations
• High-yielding plant cell line development without genetic modifications
