Von Recklinghausen (1863) probably observed what later came to be called mast cells, however his description did not lead to their identification as a specific cell type. Ehrlich (1878), identified mast cells based on the metachromatic staining of their cytoplasmic granules in connective tissue. These cells, which are often found near vessels and nerves, are of various shapes. The granules contain a paracrystalline matrix with lamellar or spiral and volute matrices. Preformed mediators stored in specific granules can be released from morphologically distinct secretion types.
Mast cells are best known for their potent effector functions in allergic disorders. In recent years, however, mast cells have been identified to be involved in a surprisingly complex range of immune functions that go far beyond allergies and include the development of autoimmune disorders and peripheral tolerance, and the initiation and maintenance of adaptive and innate host responses.
Scope of the research topic:
Knowledge and the role of mast cells in health, disease and forensic practice.
Specific themes:
Role of mast cells in wound healing
Mast cells and evolution
Mast cells in immune response
Mast cells and signaling events
Mast cells and chronic wounds
Factor affecting the mast cell functional role
Mast cells function in vivo
Mast cells in autism
Mast cells in angiogenesis
Contact among mast cells and other cellular types
Mast cells and lesion vitality
Photobiomodulation and mast cells
Historical aspects of mast cells
Types of manuscript:
Research Article
Review
Opinion
Brief Research Report
Perspective Article
Von Recklinghausen (1863) probably observed what later came to be called mast cells, however his description did not lead to their identification as a specific cell type. Ehrlich (1878), identified mast cells based on the metachromatic staining of their cytoplasmic granules in connective tissue. These cells, which are often found near vessels and nerves, are of various shapes. The granules contain a paracrystalline matrix with lamellar or spiral and volute matrices. Preformed mediators stored in specific granules can be released from morphologically distinct secretion types.
Mast cells are best known for their potent effector functions in allergic disorders. In recent years, however, mast cells have been identified to be involved in a surprisingly complex range of immune functions that go far beyond allergies and include the development of autoimmune disorders and peripheral tolerance, and the initiation and maintenance of adaptive and innate host responses.
Scope of the research topic:
Knowledge and the role of mast cells in health, disease and forensic practice.
Specific themes:
Role of mast cells in wound healing
Mast cells and evolution
Mast cells in immune response
Mast cells and signaling events
Mast cells and chronic wounds
Factor affecting the mast cell functional role
Mast cells function in vivo
Mast cells in autism
Mast cells in angiogenesis
Contact among mast cells and other cellular types
Mast cells and lesion vitality
Photobiomodulation and mast cells
Historical aspects of mast cells
Types of manuscript:
Research Article
Review
Opinion
Brief Research Report
Perspective Article
