Down syndrome (DS) is the most common chromosomal disorder, affecting approximately 1 in every 800 liveborn babies. DS is associated with intellectual disabilities as well as medical issues ranging from congenital heart disease, obstructive sleep apnea, celiac disease, to endocrinopathies. Endocrine disorders such as short stature, thyroid dysfunction, low bone mass, diabetes, infertility, and propensity to be overweight/obese are much more common among DS patients than in the general population. Accurate diagnostics and effective treatments for these conditions do exist, however best practices for many of these endocrine conditions for DS patients have not yet been established.
As life expectancy for individuals with DS has significantly improved, with a median age of 4 years in the 1950s to 60 years as of 2021, the medical community is challenged with further optimizing medical treatments to reduce morbidity and maximize function. Pathophysiology and management of endocrine disorders is an area of active research and of growing importance as life expectancy increases, especially where patients with DS may find themselves in occupations or environments presenting unique challenges. Medical research plays an important role as part of an expanding initiative to empower individuals with Down syndrome to reach their full potential throughout life and to upgrade their quality of life.
The recommended article types for this research topic include original studies or systematic reviews with meta-analysis. The scope for the submission involves the vast diversity of endocrine disorders in DS patients such as short stature, thyroid dysfunction, low bone mass, diabetes, infertility, and obesity.
Down syndrome (DS) is the most common chromosomal disorder, affecting approximately 1 in every 800 liveborn babies. DS is associated with intellectual disabilities as well as medical issues ranging from congenital heart disease, obstructive sleep apnea, celiac disease, to endocrinopathies. Endocrine disorders such as short stature, thyroid dysfunction, low bone mass, diabetes, infertility, and propensity to be overweight/obese are much more common among DS patients than in the general population. Accurate diagnostics and effective treatments for these conditions do exist, however best practices for many of these endocrine conditions for DS patients have not yet been established.
As life expectancy for individuals with DS has significantly improved, with a median age of 4 years in the 1950s to 60 years as of 2021, the medical community is challenged with further optimizing medical treatments to reduce morbidity and maximize function. Pathophysiology and management of endocrine disorders is an area of active research and of growing importance as life expectancy increases, especially where patients with DS may find themselves in occupations or environments presenting unique challenges. Medical research plays an important role as part of an expanding initiative to empower individuals with Down syndrome to reach their full potential throughout life and to upgrade their quality of life.
The recommended article types for this research topic include original studies or systematic reviews with meta-analysis. The scope for the submission involves the vast diversity of endocrine disorders in DS patients such as short stature, thyroid dysfunction, low bone mass, diabetes, infertility, and obesity.