Sepsis, a dysregulated immune response to infection resulting in end-organ damage and potentially death, is a major public health threat. Although the pathogenesis of sepsis is multifactorial and incompletely understood, increasing evidence suggests that gut microbiome disruption predisposes to sepsis and negatively affects sepsis outcomes. The gut microbiome modulates multiple responses to sepsis and is a potential therapeutic target for sepsis. It affects host susceptibility and response to sepsis through a number of pathways. Gut microbiome disruption appears to be a risk factor for sepsis and subsequent organ dysfunction.
This Research Topic is focused on sepsis or ischemia/reperfusion-induced changes in gut microbiota and metabolites, as well as the roles, mechanisms and clinical biomarkers of gut microbiota and metabolites in sepsis or ischemia/reperfusion injury.
We welcome Original Research articles, Methods, Reviews, Mini-reviews and perspectives on but not limited to the following sub-themes:
1. The effect of the gut microbiome and its metabolites on the pathogenesis and severity in Sepsis or organs (Intestine, liver, kidney, heart, brain, etc.) I/R injury.
2. The changes in the richness, diversity and community composition of the gut microbiota as well as the inflammation and immune profiles in Sepsis or organs (Intestine, liver, kidney, heart, brain, etc.) I/R injury.
3. The application of cutting-edge omics research and other technologies in the microbiome and Sepsis or organs (Intestine, liver, kidney, heart, brain, etc.) I/R injury, such as metagenomics, transcriptomics, metabolomics, and proteomics.
4. Comparison of the microbiota in Sepsis or organs (Intestine, liver, kidney, heart, brain, etc.) I/R injury with the clinical indicators of patients undergoing shock, intestinal obstruction, mesenteric artery embolism, abdominal aortic aneurysm surgery, cardiopulmonary bypass surgery, etc.
Sepsis, a dysregulated immune response to infection resulting in end-organ damage and potentially death, is a major public health threat. Although the pathogenesis of sepsis is multifactorial and incompletely understood, increasing evidence suggests that gut microbiome disruption predisposes to sepsis and negatively affects sepsis outcomes. The gut microbiome modulates multiple responses to sepsis and is a potential therapeutic target for sepsis. It affects host susceptibility and response to sepsis through a number of pathways. Gut microbiome disruption appears to be a risk factor for sepsis and subsequent organ dysfunction.
This Research Topic is focused on sepsis or ischemia/reperfusion-induced changes in gut microbiota and metabolites, as well as the roles, mechanisms and clinical biomarkers of gut microbiota and metabolites in sepsis or ischemia/reperfusion injury.
We welcome Original Research articles, Methods, Reviews, Mini-reviews and perspectives on but not limited to the following sub-themes:
1. The effect of the gut microbiome and its metabolites on the pathogenesis and severity in Sepsis or organs (Intestine, liver, kidney, heart, brain, etc.) I/R injury.
2. The changes in the richness, diversity and community composition of the gut microbiota as well as the inflammation and immune profiles in Sepsis or organs (Intestine, liver, kidney, heart, brain, etc.) I/R injury.
3. The application of cutting-edge omics research and other technologies in the microbiome and Sepsis or organs (Intestine, liver, kidney, heart, brain, etc.) I/R injury, such as metagenomics, transcriptomics, metabolomics, and proteomics.
4. Comparison of the microbiota in Sepsis or organs (Intestine, liver, kidney, heart, brain, etc.) I/R injury with the clinical indicators of patients undergoing shock, intestinal obstruction, mesenteric artery embolism, abdominal aortic aneurysm surgery, cardiopulmonary bypass surgery, etc.