Heart failure is an umbrella term which refers to conditions that reflect abnormal functioning of the heart muscles and associated structures. This condition encompasses a number of cardiac disease phenotypes that fall into the broad classification of heart failure with reduced ejection fraction (HFrEF) or heart failure with preserved ejection fraction (HFpEF). In general, the diagnosis and management of the disease follows a standardized pre-defined formula that may not accurately reflect the specific disease phenotype. In recent years, there has been greater awareness of the applications of small molecule therapeutics for certain diseases. However, our understanding of the precise molecular and cellular mechanisms that contribute to onset, progression and therefore potential treatment of various types of heart failure remains to be elucidated. This includes the question of what the question relationship between genetic pre-disposition and environmental influence is important for treatment and prevention of heart failure.
In this Research Topic, we intend to delve into the recent advances in molecular and cellular mechanisms of heart failure. We are seeking papers that provide novel insights into the pathogenesis and pathophysiological basis of disease leading to structural and functional changes in the heart. We hope to address current gaps in our understanding of diseases of HFrEF and HFpEF in children and adults.
Examples include but are not limited to:
1) Primary and second forms of myocardial diseases.
2) Familial and idiopathic cardiomyopathies.
3) Dilated cardiomyopathy.
4) Hypertrophic cardiomyopathy.
5) Peripartum cardiomyopathy.
6) Mitochondrial cardiomyopathy.
This Research Topic welcomes original research articles, brief research reports, methods papers, full reviews, mini focused reviews, systematic reviews and perspectives. This may involve basic science studies utilizing novel approaches in molecular and cellular biology, multi-omics, physiological and biophysical approaches in human, animal or IPSC models that help critically inform the biological mechanisms and pathways causing heart failure in humans. We also welcome insights that promote translation of genetic biomarkers and novel small molecules into clinical practice.
Heart failure is an umbrella term which refers to conditions that reflect abnormal functioning of the heart muscles and associated structures. This condition encompasses a number of cardiac disease phenotypes that fall into the broad classification of heart failure with reduced ejection fraction (HFrEF) or heart failure with preserved ejection fraction (HFpEF). In general, the diagnosis and management of the disease follows a standardized pre-defined formula that may not accurately reflect the specific disease phenotype. In recent years, there has been greater awareness of the applications of small molecule therapeutics for certain diseases. However, our understanding of the precise molecular and cellular mechanisms that contribute to onset, progression and therefore potential treatment of various types of heart failure remains to be elucidated. This includes the question of what the question relationship between genetic pre-disposition and environmental influence is important for treatment and prevention of heart failure.
In this Research Topic, we intend to delve into the recent advances in molecular and cellular mechanisms of heart failure. We are seeking papers that provide novel insights into the pathogenesis and pathophysiological basis of disease leading to structural and functional changes in the heart. We hope to address current gaps in our understanding of diseases of HFrEF and HFpEF in children and adults.
Examples include but are not limited to:
1) Primary and second forms of myocardial diseases.
2) Familial and idiopathic cardiomyopathies.
3) Dilated cardiomyopathy.
4) Hypertrophic cardiomyopathy.
5) Peripartum cardiomyopathy.
6) Mitochondrial cardiomyopathy.
This Research Topic welcomes original research articles, brief research reports, methods papers, full reviews, mini focused reviews, systematic reviews and perspectives. This may involve basic science studies utilizing novel approaches in molecular and cellular biology, multi-omics, physiological and biophysical approaches in human, animal or IPSC models that help critically inform the biological mechanisms and pathways causing heart failure in humans. We also welcome insights that promote translation of genetic biomarkers and novel small molecules into clinical practice.