Adenocarcinoma is a type of malignant tumor derived from the glandular epithelium and there is an ongoing need to develop curative treatment regimens associated with low toxicity and reliable prognostic biomarkers. Although conventional therapies such as surgery, chemotherapy, and radiotherapy can be used to kill most tumor cells, they often can not cure cancer completely. Cancer stem cells (CSCs) are a group of cancer cells with self-renewal and differentiation properties that make them the engines of tumor growth and evolution. Although traditional anti-cancer therapies are effective against most tumor cells, some CSCs populations are resistant to conventional treatments, leading to cancer recurrence and metastasis. Selective targeting of CSC-specific molecular markers or signal pathways is a promising opportunity to treat malignant tumors. Meanwhile, a better understanding of the heterogeneity and plasticity of CSCs is the key to implementing CSC-targeted therapy in clinical practice.
Translating research findings from CSCs biology into clinical practice holds great promise for improving adenocarcinoma management but is still in its infancy. Exploring specific molecular markers, signaling pathways, and metabolic vulnerabilities for targeted therapy specific to CSCs but not affecting normal stem cells is a hotspot in translational CSCs research. This Research Topic serves as a communication platform for the up-to-date CSC-targeted therapy research, providing readers with the latest developments in the field.
This Research Topic aims to introduce the latest progress in basic research and clinical application of cancer stem cell-targeted therapy. We welcome Original Research Articles, Reviews, and Mini Reviews. Topics of interest include, but are not limited to:
- Studies on the plasticity and heterogeneity of CSCs and their efficacy in the targeted therapy in adenocarcinoma
- Discoveries of clinically relevant biomarkers of CSCs in adenocarcinoma
- Molecular mechanisms of CSCs involved in therapy resistance in adenocarcinoma
- The effect of microenvironment on CSC-targeted therapy in adenocarcinoma
- Studies on CSCs in the development of adenocarcinoma metastasis
- Development of CSC-specific therapies in adenocarcinoma
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Adenocarcinoma is a type of malignant tumor derived from the glandular epithelium and there is an ongoing need to develop curative treatment regimens associated with low toxicity and reliable prognostic biomarkers. Although conventional therapies such as surgery, chemotherapy, and radiotherapy can be used to kill most tumor cells, they often can not cure cancer completely. Cancer stem cells (CSCs) are a group of cancer cells with self-renewal and differentiation properties that make them the engines of tumor growth and evolution. Although traditional anti-cancer therapies are effective against most tumor cells, some CSCs populations are resistant to conventional treatments, leading to cancer recurrence and metastasis. Selective targeting of CSC-specific molecular markers or signal pathways is a promising opportunity to treat malignant tumors. Meanwhile, a better understanding of the heterogeneity and plasticity of CSCs is the key to implementing CSC-targeted therapy in clinical practice.
Translating research findings from CSCs biology into clinical practice holds great promise for improving adenocarcinoma management but is still in its infancy. Exploring specific molecular markers, signaling pathways, and metabolic vulnerabilities for targeted therapy specific to CSCs but not affecting normal stem cells is a hotspot in translational CSCs research. This Research Topic serves as a communication platform for the up-to-date CSC-targeted therapy research, providing readers with the latest developments in the field.
This Research Topic aims to introduce the latest progress in basic research and clinical application of cancer stem cell-targeted therapy. We welcome Original Research Articles, Reviews, and Mini Reviews. Topics of interest include, but are not limited to:
- Studies on the plasticity and heterogeneity of CSCs and their efficacy in the targeted therapy in adenocarcinoma
- Discoveries of clinically relevant biomarkers of CSCs in adenocarcinoma
- Molecular mechanisms of CSCs involved in therapy resistance in adenocarcinoma
- The effect of microenvironment on CSC-targeted therapy in adenocarcinoma
- Studies on CSCs in the development of adenocarcinoma metastasis
- Development of CSC-specific therapies in adenocarcinoma
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.