Shock is a common but fatal complication during severe trauma, hemorrhage, sepsis, burn, heatstroke, or allergic reaction. Uncontrolled hemorrhage represents a major preventable cause of death in trauma patients, and understanding physiological responses to hemorrhage has led to significant improvements in different areas of pre-hospital care and patient survival. However, controversy still exists with appropriate type and timing of resuscitation fluids, permissive hypotension, controlling coagulopathy and multiple organ failure, activation of the immune system, goal-directed hemostasis, and antifibrinolytics in severely injured patients. Specifically, understanding the pathophysiological mechanisms that play a role patient survival and predicting patient outcomes is lacking.
The goal is to further understand mechanisms for different types of shock-induced injuries and use a variety of methodologies and models to address potential therapeutic strategies that decrease patient complications, enhance tissue tolerance to ischemia, or other treatments that might have a significant impact on patient survival.
This Research Topic welcomes clinical and basic science research or summaries on different types of shock-associated injuries, including etiology, mechanisms, pathophysiology, and potential therapeutics targeting patient survival, multiple organ failure, abnormal coagulation, tissue tolerance to ischemia, or optimal strategies for trauma resuscitation. In addition to clinical and animal approaches, atypical methodologies are also welcome including retrospective analyses, predictive analytic methods, machine learning, and physiological modeling.
Shock is a common but fatal complication during severe trauma, hemorrhage, sepsis, burn, heatstroke, or allergic reaction. Uncontrolled hemorrhage represents a major preventable cause of death in trauma patients, and understanding physiological responses to hemorrhage has led to significant improvements in different areas of pre-hospital care and patient survival. However, controversy still exists with appropriate type and timing of resuscitation fluids, permissive hypotension, controlling coagulopathy and multiple organ failure, activation of the immune system, goal-directed hemostasis, and antifibrinolytics in severely injured patients. Specifically, understanding the pathophysiological mechanisms that play a role patient survival and predicting patient outcomes is lacking.
The goal is to further understand mechanisms for different types of shock-induced injuries and use a variety of methodologies and models to address potential therapeutic strategies that decrease patient complications, enhance tissue tolerance to ischemia, or other treatments that might have a significant impact on patient survival.
This Research Topic welcomes clinical and basic science research or summaries on different types of shock-associated injuries, including etiology, mechanisms, pathophysiology, and potential therapeutics targeting patient survival, multiple organ failure, abnormal coagulation, tissue tolerance to ischemia, or optimal strategies for trauma resuscitation. In addition to clinical and animal approaches, atypical methodologies are also welcome including retrospective analyses, predictive analytic methods, machine learning, and physiological modeling.