Metastatic dissemination of primary tumors represents the most lethal attribute of cancer and critically limits successful therapy in many tumor entities. To improve this clinical outcome, the identification of biomarkers to identify cancer patients at high risk for metastasis and key drivers for metastatic dissemination is extremely important.
Recently, a novel and previously undescribed gene, Metastasis-Associated in Colon Cancer 1 (MACC1), was found to be involved in fundamental processes like proliferation, migration, invasiveness, and metastasis in xenografted and transgenic mice. In addition to its key role in metastatic formation, MACC1 has also been established as a prognostic and predictive biomarker for tumor progression and metastasis in more than 20 solid cancers.
In this Research Topic, we will address all relevant basic and translational research focused on, but not limited to:
- MACC1 transcriptional regulation mechanisms (including lncRNA, and miRNA networks) as well as translational/post-translational regulations
- The role of MACC1 on signaling cascades and target genes involved in cancer
- MACC1 diagnostic and prognostic role in different types of cancers
- Therapeutic interventions aiming at MACC1 itself or/and on the signaling pathways thereof
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Metastatic dissemination of primary tumors represents the most lethal attribute of cancer and critically limits successful therapy in many tumor entities. To improve this clinical outcome, the identification of biomarkers to identify cancer patients at high risk for metastasis and key drivers for metastatic dissemination is extremely important.
Recently, a novel and previously undescribed gene, Metastasis-Associated in Colon Cancer 1 (MACC1), was found to be involved in fundamental processes like proliferation, migration, invasiveness, and metastasis in xenografted and transgenic mice. In addition to its key role in metastatic formation, MACC1 has also been established as a prognostic and predictive biomarker for tumor progression and metastasis in more than 20 solid cancers.
In this Research Topic, we will address all relevant basic and translational research focused on, but not limited to:
- MACC1 transcriptional regulation mechanisms (including lncRNA, and miRNA networks) as well as translational/post-translational regulations
- The role of MACC1 on signaling cascades and target genes involved in cancer
- MACC1 diagnostic and prognostic role in different types of cancers
- Therapeutic interventions aiming at MACC1 itself or/and on the signaling pathways thereof
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.