Burkholderia are considered an ubiquitous Gram-negative bacteria found in soil, water, plant nodules, seeds and flowers. The common pathogens under this genus are Burkholderia pseudomallei and Burkholderia mallei. These pathogens are known to cause potentially fatal infections in humans, especially immunocompromised individuals. Among the different species, B. pseudomallei is known to cause Melioidosis, an acute or chronic clinical infection that targets various organs of the body such as liver, spleen, lungs, prostate and kidneys. Transmission of the infection generally occurs through contact with the soil or water where they normally reside.
There are continuous and ongoing efforts in understanding the structural features and mode of action of these pathogens vital in driving scientific discovery towards prevention and treatment strategies against these infections. Through this research topic, we aim to explore the scientific gaps associated with our understanding of Burkholderia species and its importance to design better drug and treatment modalities.
The current Research Topic aims to highlight the latest scientific findings on these pathogens in the following areas:
1. Mode of transmission between the hosts.
2. Pathogenesis and resistance mechanisms developed by the species.
3. Host-pathogen interaction and immune evasion mechanisms.
4. Prevention strategies to stem the infection.
5. Novel treatment strategies against the infection.
Burkholderia are considered an ubiquitous Gram-negative bacteria found in soil, water, plant nodules, seeds and flowers. The common pathogens under this genus are Burkholderia pseudomallei and Burkholderia mallei. These pathogens are known to cause potentially fatal infections in humans, especially immunocompromised individuals. Among the different species, B. pseudomallei is known to cause Melioidosis, an acute or chronic clinical infection that targets various organs of the body such as liver, spleen, lungs, prostate and kidneys. Transmission of the infection generally occurs through contact with the soil or water where they normally reside.
There are continuous and ongoing efforts in understanding the structural features and mode of action of these pathogens vital in driving scientific discovery towards prevention and treatment strategies against these infections. Through this research topic, we aim to explore the scientific gaps associated with our understanding of Burkholderia species and its importance to design better drug and treatment modalities.
The current Research Topic aims to highlight the latest scientific findings on these pathogens in the following areas:
1. Mode of transmission between the hosts.
2. Pathogenesis and resistance mechanisms developed by the species.
3. Host-pathogen interaction and immune evasion mechanisms.
4. Prevention strategies to stem the infection.
5. Novel treatment strategies against the infection.
