Immunometabolism refers to the changes of intracellular metabolic pathways that affect the
function of immune cells, and includes glycolysis, tricarboxylic acid cycle, fatty acid metabolism,
pentose phosphate pathway, etc. Metabolic reprogramming plays a critical role in the
important cellular metabolic alterations that occur during the dynamic adjustment of
function/differentiation of immune cells to enable them to adapt to extracellular environments
in infection, autoimmunity, and cancer. This reprogramming is not only the processes involved
in adenosine triphosphate (ATP) production, but also the process of producing metabolites that
can be used as immune signal molecules. A variety of immune cells with different status of
functions utilize distinct metabolic pathways to orchestrate their survival and function. The
metabolic reprogramming in different T cells and their subsets to shape immune responses is
not entirely clear and understanding how metabolic reprogramming instructs T-cell subsets not
only represents critical opportunities to delineate new avenues in their biology, but also
provides opportunities for tuning up or down T-cell function for therapeutic purposes.
The proposed Research Topic aims to provide an overview of current investigations and
understanding of immunometabolism that is intrinsically linked to cellular differentiation,
activation, function, plasticity, and survival of T cells and their subsets in infection,
autoimmunity and cancer biology. We welcome and encourage the authors to present Original
Research, Review, Mini Review, Case report and Perspective articles covering the following
subtopics:
? The metabolic properties of T-cell subsets, including T help 17 subset (Th17), regulatory
T cells, memory T cells, and ?dT cells etc, in infection, autoimmunity and cancer
? The involvement of metabolic reprogramming in the survival of tissue resident memory
T cells
? The involvement of metabolic reprogramming in the plasticity of T-cell subsets,
especially the plasticity between regulatory T cells and Th17 cells
? Metabolic interventions in tumor microenvironments and autoimmune pathologies that
can improve or suggest possible new targets for T-cell therapies
? The contribution of non-immune cells (keratinocytes, fibroblasts, cancer cells, etc) to the
metabolic reprogramming of T-cell subsets
? Metabolomic and proteomics landscapes based on single-cell RNA sequencing (scRNA-
seq) or other platforms
? Novel research models or prospective views of immunometabolism
? Pre-clinical and clinical studies focusing on the intervention of immunometabolism,
including metformin, antibody-based therapies, statins, microbiota, etc
Immunometabolism refers to the changes of intracellular metabolic pathways that affect the
function of immune cells, and includes glycolysis, tricarboxylic acid cycle, fatty acid metabolism,
pentose phosphate pathway, etc. Metabolic reprogramming plays a critical role in the
important cellular metabolic alterations that occur during the dynamic adjustment of
function/differentiation of immune cells to enable them to adapt to extracellular environments
in infection, autoimmunity, and cancer. This reprogramming is not only the processes involved
in adenosine triphosphate (ATP) production, but also the process of producing metabolites that
can be used as immune signal molecules. A variety of immune cells with different status of
functions utilize distinct metabolic pathways to orchestrate their survival and function. The
metabolic reprogramming in different T cells and their subsets to shape immune responses is
not entirely clear and understanding how metabolic reprogramming instructs T-cell subsets not
only represents critical opportunities to delineate new avenues in their biology, but also
provides opportunities for tuning up or down T-cell function for therapeutic purposes.
The proposed Research Topic aims to provide an overview of current investigations and
understanding of immunometabolism that is intrinsically linked to cellular differentiation,
activation, function, plasticity, and survival of T cells and their subsets in infection,
autoimmunity and cancer biology. We welcome and encourage the authors to present Original
Research, Review, Mini Review, Case report and Perspective articles covering the following
subtopics:
? The metabolic properties of T-cell subsets, including T help 17 subset (Th17), regulatory
T cells, memory T cells, and ?dT cells etc, in infection, autoimmunity and cancer
? The involvement of metabolic reprogramming in the survival of tissue resident memory
T cells
? The involvement of metabolic reprogramming in the plasticity of T-cell subsets,
especially the plasticity between regulatory T cells and Th17 cells
? Metabolic interventions in tumor microenvironments and autoimmune pathologies that
can improve or suggest possible new targets for T-cell therapies
? The contribution of non-immune cells (keratinocytes, fibroblasts, cancer cells, etc) to the
metabolic reprogramming of T-cell subsets
? Metabolomic and proteomics landscapes based on single-cell RNA sequencing (scRNA-
seq) or other platforms
? Novel research models or prospective views of immunometabolism
? Pre-clinical and clinical studies focusing on the intervention of immunometabolism,
including metformin, antibody-based therapies, statins, microbiota, etc
