With unremittingly innovations, biomaterials have been revolutionizing multiple fields including but not limited to pharmaceutics, disease theragnostic, synthetic biology and tissue engineering. In this case, molecule self-assembly offers a biomimetic and achievable strategy to construct and/or synthesis biomaterials exploiting a range of non-covalent interactions, including hydrogen bonding, van der Waals forces, electrostatic, hydrophobic, and p–p stacking interactions, and metal coordination. In this way, self-assembled biomaterials are endowed with the biological, chemical, or physical responsiveness to pH, redox, enzymes, temperature, light, sound or stress, thereby achieving the biofunction for the diagnose and therapy of injury or disease by the regulation of transcription, proteins, or cellular behaviors of tissues and cells.
For the development of biocompatible materials with intensive bioaction and optimized immunoprotection, a growing number of efforts have focused on expanding acknowledge in the interaction between biomaterials and human body. From fundamental research to translational application, bionic self-assembly was blended with bio-orthogonal and biocompatible chemistries including living polymerization and click chemistry. While many successes have been achieved in the development of biomaterials possessing with the degradable and bioactive features in these methods, it remains a challenge in regard to the reliable strategy of self-assemblies with the harmony among components, structures and functions to obtain a series of clinically translational biomaterials with the predictable efficiency and safety. The efficiency and quality of therapy were still limited by the efficiency and uniformity of the assembly, the stability of the formulation, the safety of the decomposition, the ease of scalability and batch-to-batch reproducibility. Considering that, this Research Topic aims to bring together leading researchers to exchange and share their findings, opinions, and perspectives on tracking these questions.
The main scope of the Research Topic encompasses new concepts in self-assembly biomaterials design, preparation and evaluation, studies into the new strategy and mechanism of self-assembly, the interaction of functional and smart biomaterials with the body, and the biological effect of materials in vitro and in vivo. This Research Topic proposes to publish original research and review articles, mini-reviews, and opinions on potential topics, including but not limited to:
-Discovery of novel self-assembly strategies and research of assembly mechanism
-Design and development of self-assembly smart nanomaterials, polymers, hydrogels
-Self-assembly nanomedicine for anti-tumor, antibacterial or tissue engineering
-Self-assembly and responsive nanocomposite hydrogels for therapy of injury
-Smart Biomaterials for Immune Engineering.
-Self-assembly smart biomaterials based on 3D bioprinting
-Biocompatibility and biodegradation of self-assembly smart biomaterials
With unremittingly innovations, biomaterials have been revolutionizing multiple fields including but not limited to pharmaceutics, disease theragnostic, synthetic biology and tissue engineering. In this case, molecule self-assembly offers a biomimetic and achievable strategy to construct and/or synthesis biomaterials exploiting a range of non-covalent interactions, including hydrogen bonding, van der Waals forces, electrostatic, hydrophobic, and p–p stacking interactions, and metal coordination. In this way, self-assembled biomaterials are endowed with the biological, chemical, or physical responsiveness to pH, redox, enzymes, temperature, light, sound or stress, thereby achieving the biofunction for the diagnose and therapy of injury or disease by the regulation of transcription, proteins, or cellular behaviors of tissues and cells.
For the development of biocompatible materials with intensive bioaction and optimized immunoprotection, a growing number of efforts have focused on expanding acknowledge in the interaction between biomaterials and human body. From fundamental research to translational application, bionic self-assembly was blended with bio-orthogonal and biocompatible chemistries including living polymerization and click chemistry. While many successes have been achieved in the development of biomaterials possessing with the degradable and bioactive features in these methods, it remains a challenge in regard to the reliable strategy of self-assemblies with the harmony among components, structures and functions to obtain a series of clinically translational biomaterials with the predictable efficiency and safety. The efficiency and quality of therapy were still limited by the efficiency and uniformity of the assembly, the stability of the formulation, the safety of the decomposition, the ease of scalability and batch-to-batch reproducibility. Considering that, this Research Topic aims to bring together leading researchers to exchange and share their findings, opinions, and perspectives on tracking these questions.
The main scope of the Research Topic encompasses new concepts in self-assembly biomaterials design, preparation and evaluation, studies into the new strategy and mechanism of self-assembly, the interaction of functional and smart biomaterials with the body, and the biological effect of materials in vitro and in vivo. This Research Topic proposes to publish original research and review articles, mini-reviews, and opinions on potential topics, including but not limited to:
-Discovery of novel self-assembly strategies and research of assembly mechanism
-Design and development of self-assembly smart nanomaterials, polymers, hydrogels
-Self-assembly nanomedicine for anti-tumor, antibacterial or tissue engineering
-Self-assembly and responsive nanocomposite hydrogels for therapy of injury
-Smart Biomaterials for Immune Engineering.
-Self-assembly smart biomaterials based on 3D bioprinting
-Biocompatibility and biodegradation of self-assembly smart biomaterials